Dr. Aniket Arun Kuvalekar

Research Programmes

Major focus of research under diabetes program is to study the long-term effects of antidiabetic drugs, visceral obesity as well as lifestyle on lipid imbalance in type 2 diabetes mellitus and its relation with endocrine dysfunction of adipose tissue and occurrence of dyslipidemia. The mechanism of action of time-tested ayurvedic and herbal medicine as well as the neutraceuticals is studied by interventional studies in animal models.

The program also has a societal approach which concentrates on generating awareness about type 2 diabetes mellitus by delivering awareness lectures at colleges and different communities. An effort is specifically made through these lecture to impress the importance of the preventive measures towards type 2 diabetes mellitus.

Publications

• NCBI Accessions: 11
• International Reference Book: 1
• Research Papers: 38

• DQ145756: First report of 18S rDNA sequencing in Ravenelia esculenta Naras. and Thirum.
  Title: Sequence of 18s rDNA region of Ravenelia esculenta
• JN184626 Uromyces hobsonii plasma membrane (H+) ATPase gene sequence
  Title:Plasma membrane H+ ATPase from rust pathogen Uromyces hobsonii expressed during stages of gall formation in host Jasminum officinale
• JN184627: Uromyces hobsonii invertase gene sequence
  Title: Invertase gene from rust pathogen Uromyces hobsonii expressed during stages of gall formation in host Jasminum officinale
• JN184628: Uromyces hobsonii peptidase gene sequence
  Title: Peptidase gene from rust pathogen Uromyces hobsonii expressed during stages of gall formation in host Jasminum officinale
• JN184629 Uromyces hobsonii lipid transfer protein gene sequence
  Title: Lipid transfer protein gene from rust pathogen Uromyces hobsonii expressed during stages of gall formation in host Jasminum officinale
• JN184630 Uromyces hobsonii halo-acid dehalogenase gene sequence
  Title: Halo-acid dehalogenase gene from rust pathogen Uromyces hobsonii expressed during stages of gall formation in host Jasminum officinale
• JX271492 Fragaria x ananassa anthocyanidin reductase gene sequence
  Title: Fragaria x ananassa cultivar Sweet Charlie anthocyanidin reductase (ANR) mRNA, complete cds
• KC984526: Linum usitatissimum lipid transfer protein 1 gene
  Title: Isolation, cloning and characterization of lipid transfer protein from flax (Linum usitassimum)
• KC984527 Linum usitatissimum lipid transfer protein 2 gene
  Title: Isolation, cloning and characterization of lipid transfer protein from flax (Linum usitassimum)
• KC984528: Linum usitatissimum lipid transfer protein 3 gene
  Title: Isolation, cloning and characterization of lipid transfer protein from flax (Linum usitassimum)
• KC984529 Linum usitatissimum lipid transfer protein 5 gene
  Title: Isolation, cloning and characterization of lipid transfer protein from flax (Linum usitassimum)

Books Published: 1 (International Publisher)

Aniket Kuvalekar and Kanchanganga Gandhe. Gall forming rust fungi. Biochemical and molecular perspective of disease development: Case studies. LAP Lambert Academic Publishing, (ISBN-13: 978-3838392509; ISBN-10: 3838392507), paperback, 400 Pages. € 79.00 (Seventy nine Euros)

Selected Research Papers

• Chavan TC, Ghadge AA, Karandikar MN, Pandit VA, Ranjekar PK, Kulkarni OP, Kuvalekar AA and Mantri NL (2016). Hepatoprotective activity of Stawa, an ayurvedic formulation, from three species of Tinospora against alcohol induced liver injury in rats. Alternative Therapies in Health and Medicine (In Press) (IF: 1.5)
• A Ghadge, A Harsulkar, M Karandikar, V Pandit and A Kuvalekar (2016). Comparative anti-inflammatory and lipid- normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats. Genes and Nutrition, OnlineFirst, DOI 10.1186/s12263-016-0518-4 (IF: 2.8)
• A Narkhede, D Kasote, A Kuvalekar, A Harsulkar and S Jagtap (2016). Amarkand: A comprehensive review on its ethnopharmacology, nutritional aspects and taxonomy. Journal of Intercultural Ethnopharmacology, OnlineFirst, DOI: 10.5455/jice.20160324054420
• V Awad, A Kuvalekar and A Harsulkar (2015). Early somatic embryogenesis and synthetic seed preparation in Taverniera cuneifolia (Roth) arn. for conservation of root cultures. International Journal of Pharma and BioSciences, 6(3): 897-906
• M Salunke, J Banjare, S Khadke, S Harke, A Kuvalekar, A Diwan, M Pankaj, S Shukla, P Ranjekar and S Bhalerao (2015). Estimation of Serum Copeptin (A Novel Marker of Metabolic Syndrome) in Patients with Type 2 Diabetes Mellitus. Journal of Obesity and Metabolic Research, 2(4): 191-194.
• S. Khadke, S. Harke, A. Ghadge, O. Kulkarni, S. Bhalerao, A. Diwan, M. Pankaj and A. Kuvalekar (2015). Association of fasting plasma glucose and serum lipids in type 2 diabetes mellitus. Indian Journal of Pharmaceutical Science, 77 (5): 630-634. (IF: 0.479)
• A. Ghadge, S. Harke, S. Khadke, A. Diwan, M. Pankaj, O. Kulkarni, P. Ranjekar, A. Harsulkar, A. A. Kuvalekar (2015). Effects of commonly used antidiabetic drugs on antioxidant enzymes and liver function test markers in type 2 diabetes mellitus subjects- Pilot study. Experimental and Clinical Endocrinology and Diabetes, E first, DOI: 10.1055/s-0035-1554654 (IF: 1.8)
• JS Dawane, VA Pandit, SS Deshpande, AA Kuvalekar, A Mandpe, A Wele and M Dalvi (2014). Evaluation of antidiabetic activity of Nishamlaki on streptozotocin induced type II diabetic rats. International Journal of Phytomedicine, 6: 595-600 (IF: 1.23)
• JS Dawane, SS Deshpande, VA Pandit, AA Kuvalekar (2014). Evaluation of Correlation of Adiponectin and Leptin Levels and Metabolic Derangement in Diabetes Mellitus. Indian Journal of Pharmacology, 45: S63. (IF: 0.68) (Abstract)
• Abhijit A. Ghadge, Shubhangi M. Harke, Suresh P. Khadke, Arundhati G. Diwan, Madhu Pankaj, Omkar P. Kulkarni, Prabhakar K. Ranjekar, Aniket A. Kuvalekar (2014). Circulatory adipocytokines and lipid profile variations in type-2 diabetic subjects: Desirable side-effects of antidiabetic drugs. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 8: 230–232
• Sandhya Rani, Pallavi Mandave, Aniket Kuvalekar and Prabhakar Ranjekar (2014). Antiglycation, Antioxidant and Antidiabetic Activity of Strawberry (Fragaria × ananassa) Fruits during Ripening Stages. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5(5): 194-203.
• Tejaswi Chavan, Amruta Mandhare, Omkar Kulkarni and Aniket Kuvalekar (2014). Nutritional evaluation of satwa, an ayurvedic formulation, of three Tinospora species from India. VRI Phytomedicine, 2(2): 53-58.
• Devyani Salunke, Rupali Mangalekar, Aniket Kuvalekar, and Abhay Harsulkar (2014). Bioconversion of alpha-linolenic acid into long chain polyunsaturated fatty acids by oleaginous fungi. International Journal of Pharma and Bio Sciences, 5 (2): (b) 27-35.
• Pallavi C. Mandave, Pankaj K. Pawar, Prabhakar K. Ranjekar, Nitin L. Mantri, Aniket A. Kuvalekar (2014). Comprehensive evaluation of in vitro antioxidant activity, total phenols and chemical profiles of two commercially important strawberry varieties. Scientia Horticulturae, 172: 124-134. (IF: 1.730)
• Vithal Awad, Aniket Kuvalekar, Abhay Harsulkar (2014). Microbial elicitation in root cultures of Taverniera cuneifolia (Roth) Arn. for elevated glycyrrhizic acid production. Industrial Crops and Products, 54: 13–16 (IF: 2.829)
• S. K. Chandekar, R. K. Nimbalkar and A. A. Kuvalekar (2014). The Seasonal Patterns in the abundance of butterflies, their biotopes and nectar food plants from Maval Tahsil, Pune District, Maharashtra, India. International Journal of Plant Animal and Environmental Sciences, 4 (1): 50-64.
• Shital Giramkar, Omkar Kulkarni, Suresh Jagtap, Aniket Kuvalekar, Sourav Mukherjee, Rutika Jagtap, Ajay Wags, Deepti Bandawane and Sonali Nipate (2013). Anticonvulsant potential of commonly practiced formulations of Brahmi (Bacopa monnieri Linn.) in Wistar rats. Journal of Pharmacy Research 7(9): 787-791.
• Pallavi Mandave, Sandhya Rani, Aniket Kuvalekar and Prabhakar Ranjekar (2013). Antiglycation, antioxidant and antidiabetic activity of mature Strawberry (Fragaria × ananassa) fruits. International Journal of Applied Biology and Pharmaceutical Technology 4(4): 168-177.
• Pallavi Ghadge, Shital Giramkar, Megha Sangwan, Omkar Kulkarni, Asmita Wele, Aniket Kuvalekar, Suresh Jagtap, Swati Gadgil (2013). In vitro free radical scavenging potential of common traditional ayurvedic extract: Kashaya and Ksheerpaka. International Journal of Pharmacy and Pharmaceutical Sciences 5(3): 676-679
• Suresh Khadke, Shweta Rani, Vithal Awad, Neelambika Meti, Elangbam Singh, Aniket Kuvalekar and Abhay Harsulkar (2013). An improved protocol for in vitro regeneration of Rubia cordifolia via organogenesis. International Journal of Plant, Animal and Environmental Sciences 3(4): 61-69.
• Sandhya Rani, Pallavi Mandave, Suresh Khadke, Suresh Jagtap, Shankar Patil and Aniket Kuvalekar (2013). Antiglycation, Antioxidant and Antidiabetic Activity of Traditional Medicinal Plant: Rubia cordifolia Linn. for Management of Hyperglycemia. International Journal of Plant, Animal and Environmental Sciences 3(3): 42-49.
• Bhagyashri Nagarkar, Suresh Jagtap, Pallavi Nirmal, Aarti Narkhede, Aniket Kuvalekar, Omkar Kulkarni, Abhay Harsulkar (2013). Comparative evaluation of anti-inflammatory potential of medicinally important plants. International Journal of Pharmacy and Pharmaceutical Sciences 5(3): 239-243.
• Abhijit Ghadge, Suresh Khadke, Amruta Kakade, Suyash Pawar, Ujwala Shinde, Omkar Kulakrni and Aniket A. Kuvalekar (2013). Awareness towards type 2 diabetes mellitus in urban population of Pune, Maharashtra, India. International Journal of Pharma and Bio Sciences 4(2): 1070-1075.
• Nagarkar Bhagyashri, Nirmal Pallavi, Shah Moxit, Kuvalekar Aniket, Kulkarni Omkar, Harsulkar Abhay, Jagtap Suresh (2013). Different Dashamoola dosage forms of Ayurved possess varied anti-inflammatory activity. World Journal of Pharmacy and Pharmaceutical Sciences; 2(5):3118-3136
• Suresh Khadke and Aniket Kuvalekar (2013). Direct somatic embryogenesis and plant regeneration from leaf and stem explants of Nothapodytes foetida: a critically endangered plant species. International Journal of Plant, Animal and Environmental Sciences 3(1): 257 – 264.
• Tejaswi Chavan, Suresh Khadke, Shubhangi Harke, Abhijit Ghadge, Manjiri Karandikar, Vijaya Pandit, Prabhakar Ranjekar, Omkar Kulkarni and Aniket Kuvalekar* (2013). Hepatoprotective effect of polyunsaturated fatty acids against repeated subacute acetaminophen dosing in rats. International Journal of Pharma and Bio Sciences 4 (2): 286 – 295.
• Tejaswi Chavan, Suresh Khadke, Shubhangi Harke, Abhijit Ghadge, Manjiri Karandikar, Vijaya Pandit, Prabhakar Ranjekar, Omkar Kulkarni and Aniket Kuvalekar (2013). Satwa from three Tinospora species exhibits differential hepatoprotective activity against repeated acetaminophen dosing in rats. Journal of Pharmacy Research 6: 123 – 128.
• Aniket Kuvalekar, Amey Redkar, Kanchanganga Gandhe and Abhay Harsulkar (2011). Peroxidase and polyphenol oxidase activities in compatible host–pathogen interaction: Insights into the susceptibility of the host. New Zealand Journal of Botany 49 (3): 351 – 359.
• S. Mukherjee, SD Jagtap, AA Kuvalekar, YB Kale, OP Kulkarni, AM Harsulkar and PK Pawar (2010). Demonstration of the potential of Hibiscus cannabinus Linn. flowers to manage oxidative stress, bone related disorders and free – radical induced DNA damage. Indian Journal of Natural Products and Resources 1(3): 322 – 327.
• Aniket Kuvalekar and Kanchanganga Gandhe (2010). Hydrogen peroxide generation and lignification by peroxidases from Acacia eburnea infected with Ravenelia esculenta. Plant, Soil and Environment, 56(9): 419 – 428.
• Aniket A. Kuvalekar and Kanchanganga R. Gandhe (2010). Associated callus culture technique for in vitro growth of rust fungi. Journal of Threatened Taxa, 2(9): 1140 – 1143.
• S. D. Jagtap, S. S. Deokule, P. K. Pawar, A. A. Kuvalekar and A. M. Harsulkar (2010). Antimicrobial Activity of some crude herbal drugs used for skin diseases by Pawara tribes of Nandurbar district. Indian Journal of Natural Products and Resources, 1(2): 216 – 220.
• Suresh Jagtap, Subhash Deokule, Sourav Mukherjee, Aniket Kuvalekar, Santosh Devkar, Abhay Harsulkar, Pankaj Pawar (2010). Assessment of nutritional value of some wild edible plants from Satpura hills of Maharashtra, India. Journal of Herbal Medicine and Toxicology, 4(1): 77 – 82.
• Kuvalekar Aniket, Pawar Pankaj, Khare Ankita, Gandhe Kanchanganga and Harsulkar Abhay (2008). Auxin – like activity of extract from hypertrophied tissue of Acacia eburnea infected with Ravenelia esculenta. Plant Cell Tissue and Organ Culture, 94: 101 – 104. (IF 3.090)
• Gandhe K. R. and A. A. Kuvalekar (2008). Biochemical and Molecular Analysis of some gall forming rust fungi from Maharashtra, India. Mycologist News, 1: 13-14.
• Gandhe K. R. and A. A. Kuvalekar (2007). Enzymatic and Hormonal Studies in Acacia eburnea infected with Ravenelia esculenta. Zoos’ Print Journal, 22 (8): 2781-2785.
• Gandhe K. R. and A. A. Kuvalekar (2007). Phylogenetic studies in Ravenelia esculenta and related rust fungi. Indian Journal of Microbiology, 47: 212 – 218. (IF 0.938)
• Kuvalekar A. A., K. R. Gandhe, Y.C. Shauche and J. Siddharth (2006). Sequence and Phylogenetic Analysis of 18S rDNA Region of Ravenelia esculenta. Journal of Mycology and Plant Pathology, 36 (2): 244-248.

Conferences, Seminars and Workshops Attended: International-3; Global-1; National-9

International:

• “Food Safety Issues – with specific emphasis on GM Food Crops”- National Chemical Laboratory, Pune, November 2010
• “II Asian Congress of Mycology and Plant Pathology”-ISMPP and Department of Botany, Osmania University, Hyderabad, December 2007. “Hydrogen peroxide generation and lignification by peroxidases from Acacia eburnea infected with Ravenelia esculenta”. (Oral Presentation and Nomination for P. R. Verma Award)
• “Biosciences, Biotechnology and Biodiversity Analysis” -PG research Center, Department of Botany, Modern College of Arts, Science and Commerce, Shivajinagar, Pune, October 2005. “Hormonal studies in Ravenelia esculenta on Acacia eburnea Willd.” (Oral Presentation) – Conferred Consolation Prize

Global:

• “Plant Health - Global Wealth” – Indian Society of Mycology and Plant Pathology and Rajasthan College of Agriculture, at Udaipur, Rajasthan-November 2005. Sequence and Phylogenetic Analysis of 18S rDNA Region of Ravenelia esculenta. (Oral Presentation) – Conferred P. R. Verma Award

National:

• “Nutrigenomics and Nanobiotechnology” – Poona College of Pharmacy – February 2009.
• “The Biotechnology in Plant Disease Management for Sustainable Crop Protection” ARI and Indian Phytopathological Society (WZ) – September 2008. “Induction of malformation in the host by rust infection: Insights into the probable role of phytohormones during disease development” “Raising in vitro cultures of a rust fungus: A breakthrough study” (Nominated for M. J. Narsimhan Award Competetion)
• “Prospecting Fungal Diversity In tropical India, Its Conservation And Applications In Biotechnology” ARI, Pune, April 2006. Enzymatic Studies in Acacia eburnea infected with Ravenelia esculenta. (Poster Presentation)
• Genetic Engineering Workshop – Department of Microbiology, Modern College of Arts, Science and Commerce, Ganeshkhind, March 2005.
• “Emerging trends in Mycology, Plant Pathology and Microbial Biotechnology” – Department of Botany, Osmania University, Hyderabad and Indian Phytopathological Society (Central Zone), December 2004.
• Workshop on Fungal Biotechnology – CAS in Botany, University of Madras, Guindy Campus, Chennai, October 2004.
• “Recent advances in management of plant diseases, technology development and applications” – Indian Phytopathological Society (IPS -WZ) and the Department of Botany, Post Graduate Research Centre, Modern College, Pune – December 2003.
• “Faculty Development Program” – The ICFAI University, Pune – September 2003.
• 26th Annual Conference and Symposium of Indian Society of Mycology and Plant Pathology (ISMPP) – UGC-SAP Department of Botany, Goa University, Goa – October 2004. Biochemical Changes in Cordia dichotoma Forst F. Prodr, During Disease Development. (Poster Presentation)