Dr. Anvita Kale
Date of Birth: 31/08/1972
Qualification: M.Sc. PhD Biochemistry
Designation: Assistant Professor
Phone: 020-24366920 (ext.311)
Research Projects Ongoing as Co PI:
- Centre for Advanced Research in “Mechanisms leading to Preeclampsia” funded by Indian Council for Medical Research (ICMR), India.(March 2017-March 2022).
- Disturbed Maternal 1-Carbon Cycle in Preeclampsia Increases Risk for Cardiometabolic Variables in Children
Research Projects Completed as Co PI:
- Maternal micronutrient status, inflammatory markers and Risk for non-communicable diseases in the offspring in a preeclamptic rat model funded by department of biotechnology (DBT), India. (March 2013-April 2016).
- Multigenerational effects of vitamin B12 deficiency/supplementation on brain development and metabolic syndrome variables in a rat model funded by department of science and technology (DST), India. (Aug 2011-Nov 2014).
- Regulation of Fatty acid desaturases and transport proteins by maternal micronutrients in human placenta funded by Indian Council for Medical Research (ICMR), India (Aug 2012- June 2013)
- Role of maternal micronutrients on brain neurotrophic factors and cognitive development in Wistar rat offspring, funded by department of biotechnology (DBT), India. (March 2010-Feb 2013).
- Recipient of the Seva Gaurav Puraskar ”Best Researcher Award”, Bharati Vidyapeeth (Deemed to be University), 26th April 2016.
- Recipient of the best poster award (for experimental nutrition) for the paper titled “Association Of One-Carbon Metabolism (Reduced Folic Acid, Vitamin B12), Docosahexaenoic Acid And Homocysteine Concentrations In Patients With Schizophrenia” at the 41st Annual meet of the Nutrition Society of India. 20th and 21st Nov 2009 at Hyderabad.
- Recipient of RAMANATHAN AWARD for the best oral presentation for the paper titled “Essential Polyunsaturated Fatty Acids and Nerve Growth Factor Levels In First Episode Schizophrenia” in the Free Communication Session of the 39th National Conference of the Nutrition Society of India held at National Institute of Nutrition, Nov 15th-16th 2007 at Hyderabad.
- The best poster award (for experimental nutrition) was awarded to the paper titled “Sensitivity Of Fetus To Of Alpha Linolenic Acid – An Essential Omega Three Fatty Acid” at the XXXVI Annual meet of the Nutrition Society of India This award was instituted by the organizers CFTRI, DFRL and University of Mysore., 5th - 6th Nov 2004 at Mysore.
- Life member of Nutrition Society of India, India
- Life member of Society for the natal effects on health in adults (SNEHA), India
NAAC, NIRF, UGC Coordinator for the institute for the year 2015-16.
- Recipient of CSIR (Council for Industrial and Scientific Research fellowship) 1994 December.
This is a national fellowship awarded for training in methods of research under the expert guidance of faculty members /scientists working in University Departments/ National Laboratories and Institutes in various fields of Science & Technology and Medical Sciences in India.
- Recipient of NCL fellowship for the period of 1993-1995 for Masters in Biochemistry from Pune University.
This is a national merit fellowship is awarded to 10 candidates annually based on a national examination conducted for over 5000 students.
- Total: 33
- Book Chapter:1
Papers Presented In International Conferences: 24
Papers Presented In National Conferences: 22
Resource Person for the CME on Basic Techniques in Research Methodology for Ayurveda “Analysis of biological fluids” held from 27th Feb to 4th March 2017 at the Interactive Research School for Health Affairs, Bharati Vidyapeeth (Deemed to be University), Pune
Neurodevelopmental disorders impair growth and development of the brain in the womb (Reynolds et al., 1999). These disorders affect approximately 12% of the global burden of disease (Reddy et al., 2013) and associated with cognitive impairment (Anjos et al., 2013). The neurodevelopmental disorders include attention deficit hyperactivity disorder (ADHD), autism (ASD), schizophrenia and dyslexia. Nutrition is one of the factors influencing the neurodevelopmental outcome. Our group will focus on the role of omega-3 fatty acids and explore the possible mechanisms through which omega 3 fatty acids may influence brain growth and development in these neurodevelopmental disorders.
The emerging role of gestational factors especially micronutrients like folic acid, vitamin B12 and omega-3 fatty acids in shaping the brain and on the influence of these intrauterine experiences on later development of neurodevelopmental disorders is my focus area of research. The nine months of intrauterine development and the first three years of postnatal life are critical for periods of development. Further, the importance of these nutrients arises from the fact that an Indian population has a low consumption of omega-3 fatty acids and is known to be deficient in Vitamin B12. Currently due to Westernisation there is also an increased consumption of a high fat diet. Further, there is a rise in burden of mental disorders in developing coutries and a need to explore the underlying mechanisms.
- Kemse NG, Kale AA, Joshi SR (2015). Maternal supplementation of omega-3 fatty acids and micronutrients reduces cardiometabolic variables in pregnancy induced hypertension rats. Life Sciences. Jun 15;155:85-93. (IF: 2.685).
- Kemse NG, Kale AA, Joshi SR. Supplementation of maternal omega-3 fatty acids to pregnancy induced hypertension Wistar rats improves IL10 and VEGF levels. Prostaglandins Leukot Essent Fatty Acids. 2016 Jan;104:25-32 (IF: 3.155)
- Rathod R, Kale A, Joshi S (2015). Novel insights into the effect of vitamin B12 and omega-3 fatty acids on brain function. Journal of Biomedical Sciences. 2016 Jan 25;23:17 (IF: 2.736)
- Rathod SR, Khaire AA, Kale AA, Joshi SR (2015). Beneficial Effects of Omega-3 Fatty Acids and Vitamin B12 Supplementation on Brain Docosahexaenoic Acid, Brain Derived Neurotrophic Factor and Cognitive Performance in the Second Generation Wistar Rats. Bio Factors. Jul 8;41(4):261-72. Aug 7. doi: 10.1002/biof.1222. Epub 2015 Aug 7 (IF: 4.504).
- Khaire AA, Kale AA, Joshi SR (2015). Maternal Omega-3 Fatty Acids and Micronutrients Modulate Fetal Lipid Metabolism: Prostaglandins Leukot Essent Fatty Acids.Jul; 98:49-55. doi: 10.1016/j.plefa.2015.04.007. Epub 2015 Apr 25. Review (IF: 3.155).
- Rathod SR, Khaire AA, Kale AA, Joshi SR (2015). Maternal Omega-3 Fatty Acid Supplementation to a Vitamin B12 Deficient Diet Normalizes Angiogenic Markers in the Pup Brain at Birth. Int J Dev Neurosci. 2015 Jun;43:43-9. doi: 10.1016/j.ijdevneu.2015.04.006. (IF: 2.380)
- Khaire A, Rathod R, Kale A, Joshi S (2015). Vitamin B12 and Omega-3 Fatty Acids Together Regulate Lipid Metabolism in Wistar Rats. Prostaglandins Leukot Essent Fatty Acids. 99:7-17. doi: 10.1016/j.plefa.2015.04.006. Epub Apr 17 (IF: 3.155).
- Khaire A, Rathod R, Kemse N, Kale A, Joshi S (2015). Supplementation of Omega-3 Fatty Acids during Gestation and Lactation to Vitamin B12 Deficient/ Supplemented Diet Improves Pregnancy Outcome and Metabolic Variables in Wistar Rats. Reproduction, Fertility and Development Jan;27(2):341-50. doi: 10.1071/RD13306 (IF: 2.400).
- Sable P, Randhir K, Kale A, Chavan-Gautam P, Joshi S (2015). Maternal micronutrients and brain global methylation patterns in the offspring. Nutr Neurosci. Jan;18(1):30-6. doi: 10.1179/1476830513Y.0000000097. Epub 2013 Nov 27 (IF: 2.616)
- Kemse NG, Kale AA, Joshi SR (2014). A combined supplementation of omega-3 fatty acids and micronutrients (Folic acid, Vitamin B12) reduces oxidative stress markers in a rat model of pregnancy induced hypertension. PloS one; Nov; 9(11):e111902 (IF: 3.057)
- Rathod R, Khaire A, Kemse N, Kale A, Joshi S (2014). Maternal Omega-3 Fatty Acid Supplementation on Vitamin B12 Rich Diet Improves Brain Omega-3 fatty acids, Neurotrophins and Cognition in the Wistar Rat Offspring. Brain Development Nov;36(10):853-63. doi: 10.1016/j.braindev.2013.12.007. Epub 2014 Jan 10) (IF: 1.785).
- Khot V, Kale A, Joshi A, Chavan-Gautam P, Joshi S. (2014). Expression of genes encoding enzymes involved in the one carbon cycle in rat placenta is determined by maternal micronutrients (Folic acid, Vitamin B12) and Omega-3 fatty acids. BioMed Research International; June; 2014:613078 (IF: 1.579)
- Sable P, Kale A, Joshi A, Joshi S (2014). Maternal micronutrient imbalance alters gene expression of BDNF, NGF, TrkB and CREB in the offspring brain at an adult age. Int J Dev Neurosci. May; 22; 34C:24-32 (IF: 2.380)
- Sable P, Kale A, Joshi S (2013). Prenatal Omega 3 fatty acid supplementation to a micronutrient imbalanced diet protects brain neurotrophins both in the cortex and hippocampus in the adult rat offspring. Metabolism Clinical and Experimental. Nov;62(11):1607-22. doi: 10.1016/j.metabol.2013.06.002. Epub 2013 Jul 9 (IF: 4.375)
- Roy S, Sable P, Khaire A, Randhir K, Kale A, Joshi S (2013) Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring. Brain and Development Mar;36(3):219-27. doi: 10.1016/j.braindev.2013.03.004. Epub 2013 Apr 23 (IF: 1.785)
- Roy S, Kale A, Dangat K, Sable P, Kulkarni A, Joshi S. (2012). Maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids: Implications for neurodevelopmental risk in the rat offspring. Brain and Development Jan; 34(1):64-71(IF: 1.785)
- Sable P, Dangat K, Kale A, Joshi S (2011). Altered brain neurotrophins at birth: consequence of Imbalance in maternal folic acid and vitamin B12 metabolism. Neuroscience Sept: 190:127-34 (IF: 3.327)
- Dangat KD, Kale AA, Joshi SR (2011). Maternal supplementation of omega 3 fatty acids to micronutrient-imbalanced diet improves lactation in rat. Metabolism (Clinical & Experimental) Sept: 60(9):1318-24. (IF: 4.375)
- Kulkarni A, Dangat K, Kale A, Sable P, Chavan-Gautam P, Joshi S (2011). Effects of altered maternal folic Acid, vitamin b(12) and docosahexaenoic Acid on placental global DNA methylation patterns in wistar rats. PLoS One. March: 10; 6(3):e17706 (IF: 3.057
- Kilari A, Mehendale S, Pisal H, Panchanadikar T, Kale A, Joshi S (2011) Nerve growth factor, birth outcome and pre-eclampsia. International Journal of Developmental Neuroscience Feb 29(1):71-5 (IF: 2.380).
- Kale A, Naphade N, Sapkale S, Kamaraju M, Pillai A, Joshi S, Mahadik S (2010). Reduced folic acid, vitamin B(12) and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: Implications for altered one-carbon metabolism. Jan Psychiatry Res.175 : 47(IF: 2.682).
- Pillai A, Kale A, Joshi S, Naphade N, Raju MSVK, Nasrallah H, Mahadik S (2010). Decreased BDNF levels in CSF of never-medicated first episode psychotic subjects: Correlation with plasma BDNF and psychopathology. The International Journal of Neuropsychopharmacology. May 27:1 (IF: 4.009).
- Kale A, Naphade N, Sapkale S, Raju MSVK, Pillai A, Joshi S, Mahadik S (2009). Reduced Cerebrospinal fluid and Plasma Nerve Growth Factor in Drug Naïve Psychotic Patients. Schizophrenia Research 115:209 (IF: 4.748).
- Kale A, Joshi S, Naphade N, Sapkale S, MSVK Raju, Pillai A, Nasrallah H, Mahadik S (2008). Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. Schizophrenia Research, 98(1-3):295-301 (IF: 4.748).
- Rao S, Kale A, Joshi S, Mahadik S (2007). Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats. Reproductive Toxicology, 24:333 (IF: 2.771).
- Rao S, Joshi S, Kale A, Hegde M, Mahadik S (2006).Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring. Metabolism, Clinical and Experimental 55:62 (IF: 4.375)
- Joshi S, Rao S, Girigosavi S, Daware M, Kale A, Hegde M (2004) Differential effects of fish oil and folic acid supplementation during pregnancy in rats on cognitive performance and serum glucose in their offspring. Nutrition, 20:465 (IF: 3.046).
- Ranjekar PK, Hinge A, Hegde MV, Ghate M, Kale A, Sitasawad S, Wagh UV, Debsikdar VB, Mahadik SP (2003). Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res, 1; 121:109-22 (IF: 2.682).
- Kale A, Joshi S and Mahadik S (2011). Novel Mechanism for Oxidative Stress in Neurodevelopmental Pathophysiology and Course of Schizophrenia. In Molecular and genetic aspects of neurodegeneration and neuroprotection. 978-1-60805-092-(2011) Editors: Akhlaq Farooqui and Tahira Farooqui, The Ohio State University, USA. Bentham E books. USA. p. 102-120