Dr. Arnab K. Ghosh

Profile

Date of Birth: 12-12-1978

Qualification: Ph.D Biotechnology (University of Calcutta, India)

Master of Science (M.Sc.) :Biochemistry (University of Calcutta, India)

Bachelor of Science (B.Sc.) :Chemistry (Hons.) Physics, Mathematics (University of Calcutta, India)

Designation: Scientist

Contacts

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: 020-24366920 (ext. 502)

Research experience:

  • April, 2013 – November, 2015

    Post-doctoral Research Scientist, Dept. of Surgery, Columbia University, New York, USA
    Research experience: Development of microbial infection resistant medical devices such as urinary catheters, central venous catheters and endotracheal tubes; development of skin and hard surface disinfectant compositions and evaluation of the efficacy of novel antimicrobial formulations

  • April, 2011 – April, 2013

    Post-doctoral Research Fellow, Dept. of Pharmacology & Physiology, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, USA
    Research experience: Elucidation of the molecular mechanism of iron-sulfur (Fe-S) cluster biogenesis in cytosol of yeast (Saccharomyces cerevisiae) cell

  • September, 2010 – April, 2011

    Post-doctoral Research Fellow, Dept. of Internal Medicine, Cardiology Division, Virginia Commonwealth University Medical Center, USA
    Research experience: Investigation of the mechanism of reactive oxygen species signaling pathway in prostate cancer cells (DU145) treated with doxorubicin and/or sildenafil

  • July 2009- September, 2010

    Research Scientist, Philips Institute of Oral & Craniofacial Molecular Biology, School of Dentistry, Virginia Commonwealth University, USA
    Research experience: Understanding the molecular mechanism of iron uptake and virulence in gram negative anaerobic oral bacteria Porphyromonas gingivalis

  • August 2002- December 2008

    Ph.D. programme at Advanced Laboratory for Plant Genetic Engineering, IIT- Kharagpur, India
    Research experience: Generation of transgenic cotton (Gossypium hirsutum L.) plants expressing a reconstructed entomocidal δ-endotoxin gene cry1Ac of Bacillus thuringiensis, offer protection against lepidopteran insects, like cotton bollworm (Helicoverpa armigera)

Areas of interest:

  • Infection control research
  • Infection resistant medical device
  • Plant bio-technology

Honors/awards:

  • Qualified in Graduate Aptitude Test in Engineering (GATE), conducted by Govt. of India

Research Programms

There is great demand for effective antimicrobial coating technologies on the surface of medical devices for preventing potential infections. My research objective is to develop a novel antimicrobial coating composition and method of producing affordable, safe and lubricious antimicrobial medical devices, such as urinary catheters, which provide a prolonged and broad spectrum antimicrobial efficacy.

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Publications

  • Transgenic expression of onion leaf lectin gene in Indian Mustard offers protection against aphid colonization: M.A. Hossain, M.K. Maiti, A. Basu, S. Sen, A.K. Ghosh and S.K. Sen. Crop Science, 46: 2022-2032 (2006)
  • Interaction of Prevotella intermedia Strain 17 Leucine-Rich Repeat Domain Protein AdpF with Eukaryotic Cells Promotes Bacterial Internalization: D. Sengupta, D.J. Kang, C. Anaya-Bergman, T. Wyant, A. K. Ghosh, H. Miyazaki and J. P. Lewis. Infection and Immunity, 82: 2637-2648 (2014)
  • Fe-S cluster biogenesis in isolated mammalian mitochondria: coordinated use of persulfide sulfur and iron and requirements for GTP, NADH, and ATP: A. Pandey, J. Pain, A. K. Ghosh, A. Dancis and D. Pain. The Journal of Biological Chemistry, 290: 640-657 (2015)
  • Evaluation of two novel alcohol-free oral rinses containing a biguanide and botanicals against ventilator-associated pneumonia pathogens using an in vitro biofilm model: A.K. Ghosh, S. Sahakian, J. Vaijanathappa, T. Biswas, S. Kapil, C. De Silva, J. Koberstein and S. Modak. Internatioanal Journal of Applied Science and Technology, 5 (6): 1-11 (2015)

Manuscripts under preparation:

  • Efficacy of a novel antimicrobial coated latex urinary catheter against common uropathogens : Arnab K. Ghosh, Anand Zanwar, Mahabaleshwar Hedge and Shanta Modak (Manuscript under preparation)

Book Chapter:

  • A Transgenic Approach for Developing Insect-Resistant Rice Plant Types: J. Bhattacharya, R. Mukherjee, A. Banga, A. Dandapat, C.C. Mandal, M.A. Hossain, N. Banerjee, A.K. Ghosh, A.H. Chaudhuri, A. Mandal, M.K. Maiti, A. Basu, D. Ghosh, S. Das, D. Basu, S. Mishra, P. Nayak and S.K. Sen. Science, Technology and Trade for Peace and Prosperity--International Rice Congress, 2006, IRRI – (Session 1.4- Breeding for Resistance to Biotic Stresses) : 245-264

Patent Application Publications:

  • Title of the invention: “BOTANICAL ANTIMICROBIAL COMPOSITIONS” Inventor’s Name: Shanta M. Modak, Santoshkumar Dongre, Jaishree Vaijanathappa, Arnab K. Ghosh; Filed on November 25, 2013; Application No. PCT/US2013/071731; Patent Application Publication No. WO 2014092999 A1, Published on June 19, 2014
  • Title of the invention: “BROAD SPECTRUM NATURAL PRESERVATIVE COMPOSITION” Inventor’s Name: Shanta M. Modak, Santoshkumar Dongre & Arnab K. Ghosh; Filed on March 14, 2014; Application No. PCT/US2014/029486; Patent Application Publication No. WO 2014144891 A2, Published on September 18, 2014
  • Title of the invention: “REDUCTION OF BIOFILMS ON MEDICAL DEVICES” Inventor’s Name: Shanta M. Modak, Ronald Citron, Santoshkumar Dongre, Nayana Baiju & Arnab K. Ghosh; Filed on February 28, 2014; Application No. 14/194,381; US Patent Application Publication No. US 2014/0178447A1, Published on June 26, 2014
  • Title of the invention: “BIO-FILM RESISTANT SURFACES” Inventor’s Name: Shanta M. Modak, Arnab K. Ghosh, Ronald Citron, Santoshkumar Dongre & Nayana Baiju; Filed on December 09, 2014; Application No. 14/564,920; US Patent Application Publication No. US 2015/0118275A1, Published on April 30, 2015

Patent Applications:

  • Title of the invention: “BOTANICAL ANTIMICROBIAL COMPOSITIONS” Inventor’s Name: Shanta M. Modak, Arnab K. Ghosh & Lauserpina Caraos; US Patent Application Filed on January 16, 2015; Serial No. 62/104,503
  • Title of the invention: “COATINGS AND METHODS FOR INFECTION RESISTANT MEDICAL DEVICES” Inventor’s Name : Shanta M. Modak, Arnab K. Ghosh, Anand Zanwar, Chathuranga C. De Silva, Santosh Dongre & Mahabaleshwar Hedge; US Patent Application Filed on May 10, 2016; Application No. 62333905.