Dr. Preeti Chavan Gautam

Profile

Date of Birth: 1/9/1979

Qualification: M.Sc. Ph.D

Designation: Assistant Professor

Contacts

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Phone: 020-24366920 (ext.313)

Research experience:

  • Mar 2011 onward: Asst. Professor, IRSHA, Bharati Vidyapeeth Deemed University, Pune
  • Aug 2009-Mar11: ICMR Research Associate, IRSHA, Bharati Vidyapeeth Deemed University, Pune
  • Jun 2002- Sep 2007: Project Fellow CSIR-NMITLI Arthritis Project, Interdisciplinary School of Health Sciences, University of Pune.

Area of interest: Placental biology

Honors/awards:

2000-2001: Prof. P. V. Sukhatame Studentship.

2009-2011: Research Associateship from Indian Council of Medical Research, Govt. of India

Professional memberships:

Member, International Society for the Study of Fatty Acids and Lipids (ISSFAL) 2016

Publications:

  • Peer Reviewed Journal articles:23
  • Book Chapters:3

Team: :

  • Alka Rani (DST-INSPIRE Fellow)
  • Prachi Pathare-Ingawale (JRF:DST-SERB project)
  • Sonal Chavan (Technical Assisstant)

Research Programme

The focus of this research programme is

  • Understanding the mechanisms involved in placental uptake, metabolism and transfer of nutrients from the mother to the fetus.
  • Understanding the role of growth factors in regulating cell survival, growth and apoptosis in the placenta and its effect on feto-placental growth and development.
  • Studies on placental mechanisms leading to preterm birth and preeclampsia.

Research projects:

Extramural

On-going project:

  • Title: Pro-neurotrophins/p75 NTR signaling contributes to increased apoptosis in preterm placentae
  • Funded by: Dept. of Science and Technology
  • Role: Principal Investigator
  • Duration: June 2017-20

    This study is planned to examine the placental expression of pro-NGF and its receptor p75NTR in preterm pregnancy and further to study the association of pro-NGF: mature NGF ratio with placental apoptosis.

Completed project:

  • Title: Epigenetic regulation of matrix metalloproteinases in preterm placenta.
  • Funded by: Dept. of Science and Technology
  • Role: Principal Investigator
  • Duration: Feb 2012-15

    This study showed an imbalance in matrix metalloproteinases (MMP-1, -2, -3,-9) and their tissue inhibitors (TIMP-1, TIMP-2) which possibly favors premature upregulation of matrix metalloproteinases leading to extracellular remodeling in the placenta thereby leading to preterm delivery. Further, we have reported differential effect of mode of delivery (vaginal Vs caesarean) on MMP levels in preterm placenta for the first time.

Intramural:

  • Title: Regional Fatty acid Metabolism and Transport in Preeclampsia Placentae.

    This study is planned to understand whether long chain polyunsaturated fatty acid (LCPUFA) metabolism and transfer is altered in different regions of the placentae in women with preeclampsia.

Publications

Publications

  • Rani A, Wadhwani N, Chavan-Gautam P, Joshi S. Altered development and function of the placental regions in preeclampsia and its association with long chain polyunsaturated fatty acids. WIRE’s Developmental Biology, 2016 (In press)
  • Rani A, Chavan-Gautam P, Mehendale S, Wagh G, Joshi S. Differential regional fatty acid distribution in normotensive and preeclampsia placenta. BBA Clinical.2015; 4:21-16.
  • Khot V, Chavan-Gautam P, Joshi S. Proposing interactions between maternal phospholipids and the one carbon cycle: A novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life. Life Sciences, 2014 pii: S0024-3205(14)00799-1
  • Khot V, Kale A, Joshi A, Chavan-Gautam P, Joshi S. Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids. BioMed Research International 2014 ;2014:613078.
  • Sundrani DP, Reddy US, Chavan-Gautam PM, Mehendale SS, Chandak GR, Joshi SR. Altered Methylation and Expression Patterns of Genes Regulating Placental Angiogenesis in Preterm Pregnancy. Reproductive Sciences. 2014 ;21(12):1508-17. 
  • Sable P, Randhir K,  Kale A, Chavan-Gautam P,  Joshi S.Maternal micronutrients and brain global methylation patterns in the offspring. Nutritional Neuroscience 2015;18(1):30-6.
  • Sundrani DP, Reddy US, Joshi AA, Mehendale SS, Chavan-Gautam PM, Hardikar AA, Chandak GR, Joshi SR. Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia. Clinical Epigenetics. 2013; 5(1):6.
  • Sundrani D, Chavan-Gautam P, Pisal H, Mehendale S, Joshi S. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. Reproduction. 2013;145(4):401-10
  • D’Souza V, Chavan-Gautam P, Joshi S. Counteracting Oxidative Stress in Pregnancy through Modulation of Maternal Micronutrients and Omega-3 Fatty Acids. Current Medicinal Chemistry. 2013;20(37):4777-83
  • Dhobale M, Chavan P, Kulkarni A, Mehendale S, Pisal H, Joshi S. Reduced folate, increased vitamin B12 and homocysteine concentrations in women delivering preterm. Annals of Nutrition and Metabolism 2012; Jul 61:7-14.
  • Sundrani DP, Chavan-Gautam PM, Pisal HR, Mehendale SS, Joshi SR (2012) Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy. PLoS ONE 2012, 7(1): e29855
  • Sundrani D, Chavan Gautam P, Mehendale S, Joshi S. Altered metabolism of maternal micronutrients and omega 3 fatty acids epigenetically regulate matrix metalloproteinases in preterm pregnancy: A novel hypothesis. Medical Hypothesis. 2011, Nov 77 (5):878-83.
  • Chavan-Gautam P, Sundrani D, Pisal H, Nimbargi V, Mehendale S, Joshi S. Gestation-dependant changes in human placental global DNA methylation levels. Molecular Reproduction and Development. 2011, 78(3):150.
  • Kulkarni A, Chavan-Gautam P, Mehendale S, Yadav H, Joshi S. Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsia. DNA and Cell Biology. 2011, 30(2): 79-84.
  • Kulkarni A, Dangat K, Kale A, Sable P, Chavan-Gautam P, Joshi S. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS ONE. 2011, 10:6(3) e17706.
  • Chavan P, Warude D, Joshi, K, Patwardhan, B. Development of SCAR marker as a complementary tool for identification of Zingiber officinale Roscoe from crude drug and multi-component formulation. Biotechnology and Applied Biochemistry. 2008, 50:61-69.
  • Warude D, Chavan P, Joshi K, Patwardhan B. Development and application of RAPD-SCAR marker for identification of Phyllanthus emblica Linn. Biological and Pharmaceutical Bulletin. 2006, 29(11):2313-2316.
  • Chavan P, Joshi K, Patwardhan B. DNA microarrays in Herbal Drug Research. Evidence-based Complementary and Alternative Medicine. 2006, 3(4):447-457.
  • Warude D, Chavan P, Joshi K, Patwardhan B. DNA isolation from fresh and dry plant samples with highly acidic tissue extracts, Plant Molecular Biology Reporter. 2003,21:1-6.
  • Joshi K, Chavan P, Warude D, Patwardhan B. Molecular markers in herbal drug technology. Current Science. 2004, 87(2): 157-165.
  • Rani A, Wadhwani N, Chavan-Gautam P, Joshi S. Altered development and function of the placental regions in preeclampsia and its association with long chain polyunsaturated fatty acids. WIRE’s Developmental Biology, 2016; 5(5):582-597
  • Rani A, Chavan-Gautam P, Mehendale S, Wagh G, Joshi S. Differential regional fatty acid distribution in normotensive and preeclampsia placenta. BBA Clinical.2015; 4:21-16.
  • Khot V, Chavan-Gautam P, Joshi S. Proposing interactions between maternal phospholipids and the one carbon cycle: A novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life. Life Sciences, 2014 pii: S0024-3205(14)00799-1
  • Khot V, Kale A, Joshi A, Chavan-Gautam P, Joshi S. Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids. BioMed Research International 2014 ;2014:613078.
  • Sundrani DP, Reddy US, Chavan-Gautam PM, Mehendale SS, Chandak GR, Joshi SR. Altered Methylation and Expression Patterns of Genes Regulating Placental Angiogenesis in Preterm Pregnancy. Reproductive Sciences. 2014 ;21(12):1508-17.
  • Sable P, Randhir K, Kale A, Chavan-Gautam P, Joshi S.Maternal micronutrients and brain global methylation patterns in the offspring. Nutritional Neuroscience 2015;18(1):30-6.
  • Sundrani DP, Reddy US, Joshi AA, Mehendale SS, Chavan-Gautam PM, Hardikar AA, Chandak GR, Joshi SR. Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia. Clinical Epigenetics. 2013; 5(1):6.
  • Sundrani D, Chavan-Gautam P, Pisal H, Mehendale S, Joshi S. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. Reproduction. 2013;145(4):401-10
  • D’Souza V, Chavan-Gautam P, Joshi S. Counteracting Oxidative Stress in Pregnancy through Modulation of Maternal Micronutrients and Omega-3 Fatty Acids. Current Medicinal Chemistry. 2013;20(37):4777-83
  • Dhobale M, Chavan P, Kulkarni A, Mehendale S, Pisal H, Joshi S. Reduced folate, increased vitamin B12 and homocysteine concentrations in women delivering preterm. Annals of Nutrition and Metabolism 2012; Jul 61:7-14.
  • Sundrani DP, Chavan-Gautam PM, Pisal HR, Mehendale SS, Joshi SR (2012) Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy. PLoS ONE 2012, 7(1): e29855
  • Sundrani D, Chavan Gautam P, Mehendale S, Joshi S. Altered metabolism of maternal micronutrients and omega 3 fatty acids epigenetically regulate matrix metalloproteinases in preterm pregnancy: A novel hypothesis. Medical Hypothesis. 2011, Nov 77 (5):878-83.
  • Chavan-Gautam P, Sundrani D, Pisal H, Nimbargi V, Mehendale S, Joshi S. Gestation-dependant changes in human placental global DNA methylation levels. Molecular Reproduction and Development. 2011, 78(3):150.
  • Kulkarni A, Chavan-Gautam P, Mehendale S, Yadav H, Joshi S. Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsia. DNA and Cell Biology. 2011, 30(2): 79-84.
  • Kulkarni A, Dangat K, Kale A, Sable P, Chavan-Gautam P, Joshi S. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS ONE. 2011, 10:6(3) e17706.
  • Chavan P, Warude D, Joshi, K, Patwardhan, B. Development of SCAR marker as a complementary tool for identification of Zingiber officinale Roscoe from crude drug and multi-component formulation. Biotechnology and Applied Biochemistry. 2008, 50:61-69.
  • Warude D, Chavan P, Joshi K, Patwardhan B. Development and application of RAPD-SCAR marker for identification of Phyllanthus emblica Linn. Biological and Pharmaceutical Bulletin. 2006, 29(11):2313-2316.
  • Chavan P, Joshi K, Patwardhan B. DNA microarrays in Herbal Drug Research. Evidence-based Complementary and Alternative Medicine. 2006, 3(4):447-457.
  • Warude D, Chavan P, Joshi K, Patwardhan B. DNA isolation from fresh and dry plant samples with highly acidic tissue extracts, Plant Molecular Biology Reporter. 2003,21:1-6.
  • Joshi K, Chavan P, Warude D, Patwardhan B. Molecular markers in herbal drug technology. Current Science. 2004, 87(2): 157-165.
  • Rani A, Chavan-Gautam P and Joshi S. Omega-3 fatty acids and risk of preeclampsia. Lipid Technology, 2017; 29(5-6): 47-51.
  • Khot V, Chavan-Gautam P, Mehendale S, Joshi S. Variable Methylation Potential in Preterm Placenta:Implication for Epigenetic Programming of the Offspring. Reproductive Sciences, 2017; 24(6):891-901.
  • Khot VV, Yadav DK, Shrestha S, Kaur L, Sundrani DP, Chavan-Gautam PM, Mehendale SS, Chandak GR, Joshi SR. Hypermethylated CpG sites in the MTR gene promoter in preterm placenta. Epigenomics. 2017; 9(7):985-996.

Book Chapters

  • Kalpana Joshi, Preeti Chavan-Gautam, Bhushan Patwardhan. Applications Of Biotechnology And Molecular Markers In Botanical Drug Standardization And Quality Assurance. In: Genetic Resources, Chromosome Engineering, and Crop Improvement Series: Medicinal Crops- Volume 6. Edited by Ram J. Singh, CRC Press (Taylor & Francis Group). 2011 ISBN:  9781420073843
  • Kalpana Joshi and Preeti Chavan. Development of Sequence Characterized Amplified Region (SCAR) from RAPD (Random Amplified Polymorphic DNA) Amplicons. In: Plant DNA Fingerprinting and Barcoding-Methods and Protocols

    Series: Methods in Molecular Biology, Vol. 862 .Sucher, Nikolaus J.; Hennell, James R.; Carles, Maria C. (Eds.) 2012 ISBN 978-1-61779-608-1.
    http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-61779-609-8_10

  • Preeti Chavan-Gautam, Tejas Shah, Kalpana Joshi. Transcriptomics and Epigenomics In: Innovative Approaches in Drug Discovery, 1st Edition 2016. Authors: Bhushan Patwardhan and Rathnam Chaguturu. ISBN: 978-0-12-801814-9.

    http://store.elsevier.com/Innovative-Approaches-in-Drug-Discovery/Bhushan-Patwardhan/isbn-9780128018149/