Dr. Preeti Chavan Gautam

Profile

Date of Birth: 1/9/1979

Qualification: M.Sc. Ph.D

Designation: Assistant Professor

Contacts

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: 020-24366920 (ext.313)

Research experience: 7 years

Area of interest: Placental biology

Honors/awards:

2000-2001: Prof. P. V. Sukhatame Studentship.

2009-2011: Research Associateship from Indian Council of Medical Research, Govt. of India

Professional memberships:

Member, International Society for the Study of Fatty Acids and Lipids (ISSFAL)

Publications: 20

Research Programme

The focus of this research programme is

  • Understanding the placental mechanisms involved in uptake, metabolism and transfer of nutrients from the mother to the fetus.
  • Understanding the role of growth factors in regulating cell survival, growth and apoptosis in the placenta and its effect on feto-placental growth and development.
  • Studies on the role of maternal nutrition/stress on placental mechanisms leading to adverse pregnancy outcomes like recurring pregnancy loss, preterm birth and preeclampsia.

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Publications

Publications

  • Rani A, Wadhwani N, Chavan-Gautam P, Joshi S. Altered development and function of the placental regions in preeclampsia and its association with long chain polyunsaturated fatty acids. WIRE’s Developmental Biology, 2016 (In press)
  • Rani A, Chavan-Gautam P, Mehendale S, Wagh G, Joshi S. Differential regional fatty acid distribution in normotensive and preeclampsia placenta. BBA Clinical.2015; 4:21-16.
  • Khot V, Chavan-Gautam P, Joshi S. Proposing interactions between maternal phospholipids and the one carbon cycle: A novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life. Life Sciences, 2014 pii: S0024-3205(14)00799-1
  • Khot V, Kale A, Joshi A, Chavan-Gautam P, Joshi S. Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids. BioMed Research International 2014 ;2014:613078.
  • Sundrani DP, Reddy US, Chavan-Gautam PM, Mehendale SS, Chandak GR, Joshi SR. Altered Methylation and Expression Patterns of Genes Regulating Placental Angiogenesis in Preterm Pregnancy. Reproductive Sciences. 2014 ;21(12):1508-17. 
  • Sable P, Randhir K,  Kale A, Chavan-Gautam P,  Joshi S.Maternal micronutrients and brain global methylation patterns in the offspring. Nutritional Neuroscience 2015;18(1):30-6.
  • Sundrani DP, Reddy US, Joshi AA, Mehendale SS, Chavan-Gautam PM, Hardikar AA, Chandak GR, Joshi SR. Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia. Clinical Epigenetics. 2013; 5(1):6.
  • Sundrani D, Chavan-Gautam P, Pisal H, Mehendale S, Joshi S. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. Reproduction. 2013;145(4):401-10
  • D’Souza V, Chavan-Gautam P, Joshi S. Counteracting Oxidative Stress in Pregnancy through Modulation of Maternal Micronutrients and Omega-3 Fatty Acids. Current Medicinal Chemistry. 2013;20(37):4777-83
  • Dhobale M, Chavan P, Kulkarni A, Mehendale S, Pisal H, Joshi S. Reduced folate, increased vitamin B12 and homocysteine concentrations in women delivering preterm. Annals of Nutrition and Metabolism 2012; Jul 61:7-14.
  • Sundrani DP, Chavan-Gautam PM, Pisal HR, Mehendale SS, Joshi SR (2012) Matrix Metalloproteinase-1 and -9 in Human Placenta during Spontaneous Vaginal Delivery and Caesarean Sectioning in Preterm Pregnancy. PLoS ONE 2012, 7(1): e29855
  • Sundrani D, Chavan Gautam P, Mehendale S, Joshi S. Altered metabolism of maternal micronutrients and omega 3 fatty acids epigenetically regulate matrix metalloproteinases in preterm pregnancy: A novel hypothesis. Medical Hypothesis. 2011, Nov 77 (5):878-83.
  • Chavan-Gautam P, Sundrani D, Pisal H, Nimbargi V, Mehendale S, Joshi S. Gestation-dependant changes in human placental global DNA methylation levels. Molecular Reproduction and Development. 2011, 78(3):150.
  • Kulkarni A, Chavan-Gautam P, Mehendale S, Yadav H, Joshi S. Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsia. DNA and Cell Biology. 2011, 30(2): 79-84.
  • Kulkarni A, Dangat K, Kale A, Sable P, Chavan-Gautam P, Joshi S. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS ONE. 2011, 10:6(3) e17706.
  • Chavan P, Warude D, Joshi, K, Patwardhan, B. Development of SCAR marker as a complementary tool for identification of Zingiber officinale Roscoe from crude drug and multi-component formulation. Biotechnology and Applied Biochemistry. 2008, 50:61-69.
  • Warude D, Chavan P, Joshi K, Patwardhan B. Development and application of RAPD-SCAR marker for identification of Phyllanthus emblica Linn. Biological and Pharmaceutical Bulletin. 2006, 29(11):2313-2316.
  • Chavan P, Joshi K, Patwardhan B. DNA microarrays in Herbal Drug Research. Evidence-based Complementary and Alternative Medicine. 2006, 3(4):447-457.
  • Warude D, Chavan P, Joshi K, Patwardhan B. DNA isolation from fresh and dry plant samples with highly acidic tissue extracts, Plant Molecular Biology Reporter. 2003,21:1-6.
  • Joshi K, Chavan P, Warude D, Patwardhan B. Molecular markers in herbal drug technology. Current Science. 2004, 87(2): 157-165.

BOOK CHAPTERS

  • Kalpana Joshi, Preeti Chavan-Gautam, Bhushan Patwardhan. Applications Of Biotechnology And Molecular Markers In Botanical Drug Standardization And Quality Assurance. In: Genetic Resources, Chromosome Engineering, and Crop Improvement Series: Medicinal Crops- Volume 6. Edited by Ram J. Singh, CRC Press (Taylor & Francis Group). 2011 ISBN:  9781420073843
  • Kalpana Joshi and Preeti Chavan. Development of Sequence Characterized Amplified Region (SCAR) from RAPD (Random Amplified Polymorphic DNA) Amplicons. In: Plant DNA Fingerprinting and Barcoding-Methods and Protocols

    Series: Methods in Molecular Biology, Vol. 862 .Sucher, Nikolaus J.; Hennell, James R.; Carles, Maria C. (Eds.) 2012 ISBN 978-1-61779-608-1.
    http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-61779-609-8_10