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About the Director

Dr. Akhilesh Chandra Mishra

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Profile

Name: Dr. Akhilesh Chandra Mishra

Date of Birth: 01-07-1950

Designation: Director

Contacts

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: 020-24366920 (ext.104)

Educational Qualification: M.Sc, Ph.D, LLB, Fellow Indian Academy of Sciences, Indian National Science Academy

Research/Training Experience

Duration Institution Particulars of work done
1979- 2015 National Institute of Virology, Pune Epidemiology and control planning of Vector borne diseases, Influenza, Chandipura viruses etc Establishment of high containment laboratories B SL-3 and BSL-4/

Research specialization

Infectious viral diseases-biology, epidemiology

Publications

  • Singh AK, Jain A, Jain B, Singh KP, Dangi T, Mohan M, Dwivedi M, Kumar R, Kushwaha RA, Singh JV, Mishra AC, Chadha MS. Viral aetiology of acute lower respiratory tract illness in hospitalised paediatric patients of a tertiary hospital: one year prospective study. Indian J Med Microbiol. 2014, 32(1):13-8.
  • Chadha MS, Hirve S, Dawood FS, Lele P, Deoshatwar A, Sambhudas S, Juvekar S, Lafond KE, Mott JA, Lal RB, Mishra AC. Burden of Seasonal and Pandemic Influenza-Associated Hospitalization during and after 2009 A(H1N1)pdm09 Pandemic in a Rural Community in India. PLoS One. 2013 May 15;8(5):e55918.
  • Kale SD, Mishra AC, Pawar SD. Suitability of specimen types for isolation of avian influenza viruses from poultry. Indian J Virol. 2013;24:391-3.
  • Ampofo WK, Baylor N, Cobey S, Cox NJ, Daves S, Edwards S, Ferguson N, Grohmann G, Hay A, Katz J, Kullabutr K, Lambert L, Levandowski R, Mishra AC, Monto A, Siqueira M, Tashiro M, Waddell AL, Wairagkar N, Wood J, Zambon M, Zhang W. Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010. Influenza Other Respir Viruses. 2013; 7 Suppl 2:52-3.
  • Sabale SS, Pawar SD, More BK, Mishra AC. Seroprevalence of pandemic influenza H1N1 (2009) & seasonal influenza viruses in pigs in Maharashtra & Gujarat States, India, 2011. Indian J Med Res. 2013;138:267-9.
  • Gupta V, Dawood FS, Rai SK, Broor S, Wigh R, Mishra AC, Lafond K, Mott JA, Widdowson MA, Lal RB, Krishnan A. Validity of clinical case definitions for influenza surveillance among hospitalized patients: results from a rural community in North India. Influenza Other Respir Viruses. 2013;7:321-9.
  • Pasricha G, Mishra AC, Chakrabarti AK. Comprehensive global amino acid sequence analysis of PB1F2 protein of influenza A H5N1 viruses and the influenza A virus subtypes responsible for the 20th-century pandemics. Influenza Other Respir Viruses. 2013; 7:497-505.
  • Dangi T, Jain B, Singh AK, Mohan M, Dwivedi M, Singh JV, Kumar R, Singh KP, Chaddha MS, Mishra AC, Jain A. Influenza virus genotypes circulating in and around Lucknow, Uttar Pradesh, India, during post pandemic period, August 2010 - September 2012. Indian J Med Res. 2014; 139:418-26.
  • Singh AK, Jain A, Jain B, Singh KP, Dangi T, Mohan M, Dwivedi M, Kumar R, Kushwaha RA, Singh JV, Mishra AC, Chhaddha MS. Viral aetiology of acute lower respiratory tract illness in hospitalised paediatric patients of a tertiary hospital: one year prospective study. Indian J Med Microbiol. 2014; 32:13-8.
  • Chadha MS, Hirve S, Dawood FS, Lele P, Deoshatwar A, Sambhudas S, Juvekar S, Lafond KE, Mott JA, Lal RB, Mishra AC. Burden of Seasonal and Pandemic Influenza-Associated Hospitalization during and after 2009 A(H1N1)pdm09 Pandemic in a Rural Community in India. PLoS One. 2013 May 15;8(5):e55918.
  • Kasabi GS, Murhekar MV, Yadav PD, Raghunandan R, Kiran SK, Sandhya VK, Channabasappa GH, Mishra AC, Mourya DT, Mehendale SM. Kyasanur Forest disease, India, 2011-2012. Emerg Infect Dis. 2013 Feb;19(2):278-81
  • Van Kerkhove MD, Hirve S, Koukounari A, Mounts AW, Mishra AC; H1N1pdm serology working group.Estimating age-specific cumulative incidence for the 2009 influenza pandemic: a meta-analysis of A(H1N1)pdm09 serological studies from 19 countries. Influenza Other Respi Viruses. 2013 Jan 21. doi: 10.1111/irv.12074
  • Choudhary ML, Anand SP, Heydari M, Rane G, Potdar VA, Chadha MS, Mishra AC. Development of a multiplex one step RT-PCR that detects eighteen respiratory viruses in clinical specimens and comparison with real time RT-PCR. J Virol Methods. 2013 Apr;189(1):15-9.
  • Yadav PD, Sudeep AB, Mishra AC, Mourya DT. Molecular characterization of Chittoor (Batai) virus isolates from India. Indian J Med Res. 2012 Nov;136(5):792-8.
  • Yadav PD, Cherian SS, Zawar D, Kokate P, Gunjikar R, Jadhav S, Mishra AC, Mourya DT. Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. Infect Genet Evol. 2013 Mar;14:223-31.
  • Tandale BV, Pawar SD, Gurav YK, Parkhi SS, Mishra AC. Antibody persistence after Pandemic H1N1 2009 influenza vaccination among healthcare workers in Pune, India. Hum Vaccin Immunother. 2013 Jan;9(1):125-7.
  • Moorthy M, Samuel P, Peter JV, Vijayakumar S, Sekhar D, Verghese VP, Agarwal I, Moses PD, Ebenezer K, Abraham OC, Thomas K, Mathews P, Mishra AC, Lal R, Muliyil J, Abraham AM. Estimation of the burden of pandemic(H1N1)2009 in developing countries: experience from a tertiary care center in South India. PLoS One. 2012;7(9):e41507. doi: 10.1371
  • Kode SS, Pawar SD, Tandale BV, Parkhi SS, Barde TD, Mishra AC. Low Level of Cross-Reactive Antibodies to Pandemic Influenza (H1N1) 2009 Virus in Humans in Pre-Pandemic Period in Maharashtra, India. Indian J Virol. 2012 Jun; 23(1):36-8.
  • Pawar SD, Parkhi SS, Koratkar SS, Mishra AC. Receptor specificity and erythrocyte binding preferences of avian influenza viruses isolated from India. Virol J. 2012 Oct 30;9:251. doi: 10.1186/1743-422X-9-251.
  • Gurav YK, Gopalkrishna V, Shah PS, Patil DR, Mishra M, Paingankar MS, Singh A, Sathe PS, Mishra AC. An outbreak of chikungunya in Jamshedpur, Jharkhand in 2011. Indian J Med Res. 2012 Nov;136(5):886-9.
  • Gupta V, Dawood FS, Rai SK, Broor S, Wigh R, Mishra AC, Lafond K, Mott JA, Widdowson MA, Lal RB, Krishnan A (2012). Validity of clinical case definitions for influenza surveillance among hospitalized patients: results from a rural community in North India. Influenza Other Respi Viruses : Jul 16. doi: 10.1111/j.1750-2659.2012.00401.x.
  • Yadav PD, Raut CG, Shete AM, Mishra AC, Towner JS, Nichol ST, Mourya DT (2012). Detection of Nipah Virus RNA in Fruit Bat (Pteropus giganteus) from India. Am J Trop Med Hyg. Jul 16. [Epub ahead
  • Pasricha G, Mishra AC, Chakrabarti AK (2012). Comprehensive global amino acid sequence analysis of PB1F2 protein of influenza A H5N1 viruses and the influenza A virus subtypes responsible for the 20th-century pandemics. Influenza Other Respi Viruses : Jul 13. doi: 10.1111/j.1750-2659.2012.00400.x.
  • Mourya DT, Yadav PD, Shete AM, Gurav YK, Raut CG, Jadi RS, Pawar SD, Nichol ST, Mishra AC (2012). Detection, isolation and confirmation of Crimean-Congo hemorrhagic fever virus in human, ticks and animals in Ahmadabad, India, 2010-2011. PLoS Negl Trop Dis. 6(5):e1653.
  • Raut CG, Yadav PD, Towner JS, Amman BR, Erickson BR, Cannon DL, Sivaram A, Basu A, Nichol ST, Mishra AC, Mourya DT (2012). Isolation of a Novel Adenovirus from Rousettus leschenaultii Bats from India. Intervirology. 2012 May 3. [Epub ahead of print]
  • Shinde PV, Koratkar SS, Pawar SD, Kale SD, Rawankar AS, Mishra AC (2012). Serologic evidence of avian influenza H9N2 and paramyxovirus type 1 infection in emus (Dromaius novaehollandiae) in India. Avian Dis 56(1):257-260.
  • Broor S, Krishnan A, Roy DS, Dhakad S, Kaushik S, Mir MA, Singh Y, Moen A, Chadha M, Mishra AC, Lal RB (2012). Dynamic patterns of circulating seasonal and pandemic A(H1N1)pdm09 influenza viruses from 2007-2010 in and around Delhi, India. PLoS One. 7(1):e29129.
  • Mavale M, Sudeep A, Gokhale M, Hundekar S, Parashar D, Ghodke Y, Arankalle V, Mishra AC (2012). Persistence of viral RNA in chikungunya virus-infected Aedes aegypti (Diptera: Culicidae) mosquitoes after prolonged storage at 28°C. Am J Trop Med Hyg. 86(1):178-180.
  • Sarkar M, Chanda S, Chakrabarti S, Mazumdar J, Ganguly A, Chadha MS, Mishra AC (2012). Chawla-Sarkar M. Surveillance in Eastern India (2007-2009) revealed reassortment event involving NS and PB1-F2 gene segments among co-circulating influenza A subtypes. Virol J 5 : 9-13.
  • Shelke VN, Kolhapure RM, Kadam D, Sangle S, Chadha MC, Basu A, Mishra AC (2012). Pathologic study of pandemic influenza A (H1N1) 2009 cases from India. Pathol Int 62 : 36-42.
  • Mourya DT, Yadav PD, Shete AM, Gurav YK, Raut CG, Jadi RS, Pawar SD, Nichol ST, Mishra AC (2012). Detection, isolation and confirmation of Crimean-Congo hemorrhagic fever virus in human, ticks and animals in Ahmadabad, India, 2010-2011. PLoS Negl Trop Dis 6(5):e1653.
  • Tandale BV, Pawar SD, Mishra AC (2012). Immunogenicity and safety of pandemic H1N1 2009 vaccine among adults in field use, India. Vaccine 30 : 2043-2044.
  • Chadha MS, Broor S, Gunasekaran P, Potdar VA, Krishnan A, Chawla-Sarkar M, Biswas D, Abraham AM, Jalgaonkar SV, Kaur H, Klimov A, Lal RB, Moen A, Kant L, Mishra AC (2012). Multisite virological influenza surveillance in India: 2004-2008. Influenza Other Respi Viruses 6 : 196-203.
  • Prasad HB, Puranik SC, Kadam DB, Sangle SA, Borse RT, Basavraj A, Umarji PB, Mave V, Ghorpade SV, Bharadwaj R, Jamkar AV, Mishra AC (2011). Retrospective analysis of necropsy findings in patients of H1N1 and their correlation to clinical features. J Assoc Physicians India 59 : 498-500.
  • WHO Writing Group, Ampofo WK, Baylor N, Cobey S, Cox NJ, Daves S, Edwards S, Ferguson N, Grohmann G, Hay A, Katz J, Kullabutr K, Lambert L, Levandowski R, Mishra AC, Monto A, Siqueira M, Tashiro M, Waddell AL, Wairagkar N, Wood J, Zambon M, Zhang W (2012). Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010. Influenza Other Respi Viruses 6 :142-152.
  • 36. Mishra AC, Mehta M, Mourya DT, Gandhi S (2011). Crimean-Congo haemorrhagic fever in India. Lancet 23: 378.
  • Roy T, Agrawal AS, Mukherjee A, Mishra AC, Chadha MS, Kaur H, Chawla-Sarkar M (2011). Surveillance and molecular characterization of human influenza B viruses during 2006-2010 revealed co-circulation of Yamagata-like and Victoria-like strains in eastern India. Infect Genet Evol : Jun 25.
  • Wairagkar N, Chowdhury D, Vaidya S, Sikchi S, Shaikh N, Hungund L, Tomar RS, Biswas D, Yadav K, Mahanta J, Das VN, Yergolkar P, Gunasekaran P, Raja D, Jadi R, Ramamurty N, Mishra AC (2011). MeaslesNetIndia collaborators. Molecular epidemiology of measles in India, 2005-2010. J Infect Dis 204 Suppl 1: S403-13.
  • Jadi RS, Sudeep AB, Barde PV, Arankalle VA, Mishra AC (2011). Development of an inactivated candidate vaccine against Chandipura virus (Rhabdoviridae: Vesiculovirus). Vaccine. 29 : 4613-4617.
  • Arankalle VA, Bandyopadhyay BT, Ramdasi AY, Jadi R, Patil DR, Rahman M, Majumdar M, Banerjee PS, Hati AK, Goswami RP, Neogi DK, Mishra AC (2011). Genomic characterization of Nipah virus, West Bengal, India. Emerg Infect Dis. 17 : 907-909.
  •  Yadav PD, Vincent MJ, Khristova M, Kale C, Nichol ST, Mishra AC, Mourya DT (2011). Genomic analysis reveals Nairobi sheep disease virus to be highly diverse and present in both Africa, and in India in the form of the Ganjam virus variant. Infect Genet Evol. 11 : 1111-1120.
  • Cherian S, Shil P, Mishra AC (2011). Antigen-antibody docking reveals the molecular basis for cross-reactivity of the 1918 2009 influenza A/H1N1 pandemic viruses. Bioinformatics 6 : 35-38.
  • Mullick J, Cherian SS, Potdar VA, Chadha MS, Mishra AC (2011). Evolutionary dynamics of the influenza A pandemic (H1N1) 2009 virus with emphasis on Indian isolates: evidence for adaptive evolution in the HA gene. Infect Genet Evol. 11 : 997-1005.
  • Pawar SD, Tandale BV, Raut CG, Parkhi SS, Barde TD, Gurav YK, Kode SS, Mishra AC (2012). Avian influenza H9N2 seroprevalence among poultry workers in Pune, India, 2010. PLoS One 7(5):e36374.
  •  Mukherjee S, Vipat VC, Mishra AC, Pawar SD, Chakrabarti AK (2011). Pandemic (H1N1) 2009 influenza virus induces weaker host immune responses in vitro: a possible mechanism of high transmissibility. Virol J 8: 140.
  • Sudeep AB, Hundekar SL, Jacob PG, Balasubramanian R, Arankalle VA, Mishra AC (2011). Investigation of a Chikungunya-like illness in Tirunelveli district, Tamil Nadu, India 2009-2010. Trop Med Int Health. 3 : 1365-3156.
  • Fulmali PV, Sapkal GN, Athawale S, Gore MM, Mishra AC (2011), Bondre VP. Introduction of Japanese encephalitis virus genotype I, India. Emerg Infect Dis. 17 : 319-321.
  • Basu A, Shelke V, Chadha M, Kadam D, Sangle S, Gangodkar S, Mishra AC (2011). Direct imaging of pH1N1 2009 influenza virus replication in alveolar pneumocytes in fatal cases by transmission electron microscopy. J Electron Microsc (Tokyo) 60 : 89-93.
  • Gurav YK, Raut CG, Yadav PD, Tandale BV, Sivaram A, Pore MD, Basu A, Mourya DT, Mishra AC (2011).   Buffalopox outbreak in humans and animals in Western Maharashtra, India.  Prev Vet Med. 100 : 242-247.
  • Jadi RS, Sudeep AB, Barde PV, Arankalle VA, Mishra AC (2011). Development of an inactivated candidate vaccine against Chandipura virus (Rhabdoviridae :Vesciculovirus). Vaccine 29: 4613-4617.
  • Pande S, Pandit P, Ponkshe A, Mone R, Pawar S, Mishra AC (2011). Behavioural and virological studies on a rescued Oriental White-backed Vulture Gyps bengalensis from Western Maharashtra, India. J Threatened Taxa 3: 1490-1492.
  • Shil P, Gurav YK, Chadha MS, Mishra AC (2011). Transmission dynamics of novel influenza A/H1N1 2009 outbreak in a residential school in India. Curr Sci 100 : 1177-1183
  • Mavale M, Parashar D, Sudeep A, Gokhale M, Ghodke Y, Geevarghese G, Arankalle V, Mishra AC (2010). Venereal transmission of chikungunya virus by Aedes aegypti mosquitoes (Diptera: Culicidae). Am J Trop Med Hyg 83:1242-1234.
  • Gurav YK, Tandale BV, Jadi RS, Gunjikar RS, Tikute SS, Jamgaonkar AV, Khadse RK, Jalgaonkar SV, Arankalle VA, Mishra AC (2010). Chandipura virus encephalitis outbreak among children in Nagpur division, Maharashtra, 2007. Indian J Med Res. 132: 395-9.
  • Chakrabarti AK, Vipat VC, Mukherjee S, Singh R, Pawar SD, Mishra AC (2010). Host gene expression profiling in influenza A virus-infected lung epithelial (A549) cells: a comparative analysis between highly pathogenic and modified H5N1 viruses. Virol J 7: 219.
  • Gurav YK, Pawar SD, Chadha MS, Potdar VA, Deshpande AS, Koratkar SS, Hosmani AH & Mishra AC (2010). Pandemic influenza A(H1N1) 2009 outbreak in a residential school at Panchgani, Maharashtra, India. Indian J Med Res 132: 67-71
  • Tandale BV, Pawar SD, Gurav YK, Chadha MS, Koratkar SS, Shelke VN, Mishra AC (2010). Seroepidemiology of pandemic influenza A (H1N1) 2009 virus infections in Pune, India. BMC Infect Dis. 25; 10:255.
  • Jadi RS, Sudeep AB, Kumar S, Arankalle VA, Mishra AC (2010). Chandipura virus growth kinetics in vertebrate cell lines, insect cell lines & embryonated eggs. Indian J Med Res. 132: 155-159.
  • Agrawal AS, Sarkar M, Ghosh S, Roy T, Chakrabarti S, Lal R, Mishra AC, Chadha MS, Chawla-Sarkar M (2010). Genetic characterization of circulating seasonal Influenza A viruses (2005-2009) revealed introduction of oseltamivir resistant H1N1 strains during 2009 in eastern India. Infect Genet Evol 10 : 1188-1198.
  • Sudeep AB, Jadi RS, Mishra AC (2009). Ganjam virus. Indian J Med Res 130: 514-519. Review.
  • Gurav YK, Pawar SD, Chadha MS, Potdar VA, Deshpande AS, Koratkar SS, Hosmani AH & Mishra AC (2010). Pandemic influenza A(H1N1) 2009 outbreak in a residential school at Panchgani, Maharashtra, India. Indian J Med Res 132: 67-71
  • Pawar S, Chakrabarti A, Cherian S, Pande S, Nanaware M, Raut S, Pal B, Jadhav S, Kode S, Koratkar S, Thite V, Mishra AC (2010). Avian Influenza A(H11N1) virus from a wild aquatic bird revealing a unique Eurasian-American reassortment. Virus Genes 41:14-22.
  • Mishra AC, Chadha MS, Chaudhary, ML, Potdar, V (2010). Pandemic influenza (H1N1) 2009 is associated with severe disease in India. PLoS ONE 5(5): e10540

Financial support received

Forein Funded projects

Funded by Departmrnt of Human Health Research (DHHR), CDC, Atlanta

  • Multisite influenza monitoring network in India. Duration 2004-2009; US$5,500,000
    (Grant Number: 5U50C1024407- 01-05)
  • Multisite influenza monitoring network in India. Duration 2009-2014; US$ 1,120,000
  • Enhanced H1N1 surveillence in India, Duration 2010-2012; US $ 750,000
  • Surveillence for H7N9 in India. Duration 2010-2012;US $ 100,000
  • Studies on Disease burden of Influenza- 2008-2013:US$ 3117416
    (Grant Number: 1U51IP000333-01-05)

 

Funding from India agencies

ICMR funded

  • Development of comprehensive BSL-3 laboratory. Duration 2003-2006.Rs 9.25 Cr
  • Development of BSL-4 laboratory-phase 1. Duration 2005-2009; Rs 25.0 Cr
  • Development of BSL-4 laboratory-phase 2. Duration 2009-2011 Rs 31.5 Cr

 

DST funded:

  • Part funding for BSL-4 laboratory at NIV, Pune, Duration 2008-2012; Rs 18.0 Cr

 

ICMR funded:

  • Studies on Chikungunya virus (CHIKV) - vector virus interactions, development of diagnostics Duration: July 2009 - Jan 2014; Rs.76,50,369