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Interactive Research School For Health Affairs (IRSHA), Pune

Centre for Innovation in Nutrition Health Disease (CINHD)

Dr. Mahabaleshwar Hegde

The deficiency of omega-3 fatty acids in modern food is largely responsible for the rise of degenerative disease; Prof Hegde for the last fifteen years has focused his efforts,

  • To establish the role of omega-3 fatty acids in health and disease
  • Promotion of Flax agriculture: in collaboration with AICRP Linseed Kanpur and Nagpur,
  • Use flax ALA and bio-convert to EPA, DHA (physiologically more potent omega-3 fatty acids) in chicks (egg, meat), and cattle (dairy products).
  • Flax- Biovillage concept to make the flax agriculture more lucrative to the farmers where in flax stalk can be used for handmade paper and biogas.
  • To verify and confirm the efficacy of omega-3 fatty acids and antioxidant supplementation in disease outcome along with usual treatment regimen,
  • To support farmers for growing authentic high yielding, disease resistant omega-3 rich linseed, PKV.NL260 variety.
  • To find ways and means to enrich egg, fish, milk with omega-3 fatty acids.
  • To stabilize omega-3 fatty acids in food.
  • To validate these omega-3 products for human health.
  • To popularize and commercialize omega-3 products.

Completed projects at IRSHA

S.No. Duration Funding agency Title of project Sanctioned amount
1 2001-2002 Heart Foundation Mumbai CVD co-morbidity in schizophrenic patients and omega-3 Fatty acids 10 Lakh
2 2003-04 Directorate of Science & Technology KVIC, Mumbai Honey as a base for antioxidants in Health foods 4.95 Lakhs
3 2004-06 Department of Biotechnology Egg for health in collaboration Venkateshwara Hatchery 17 Lakhs
4 2004-2005 DST.KVIC New approach to quick biogass production 4.9 Lakhs
5 2007-2014 ICAR-NAIP III Flax (Linseed) and Medicinal Plants Intervention -For Sustainable livelihood Of Farmers In Backward Districts Of Maharashtra. 235.04 Lakh
6 2009- 2014 ICAR-NAIP II Linseed – production, processing and value addition 87.16 Lakh

  • Participatory Plant Breading, seed production and commercial production of linseed variety PKVNL- 260 in Nagpur, Chandrapur and Wardha with aim to supply genetically pure seed for linseed value addition and buyback guarantee to farmers of Vidarbha.
    Scientist in charge: Dr. P. B. Ghorpade (Emeritus scientist)
  • Developing high oleic safflower genotypes through functional genomics

    The high oleic safflower genotypes developed through this non-transgenic approach can be brought into cultivation much more quickly than the genotypes developed through transgenic approaches. Such “high oleic” varieties will benefit the Indian oil industry due to cheaper availability of indigenous high oleic safflower, which can reduce the market price of the healthier higholeic safflower oil for use as frying / cooking oil as well as for industrial applications. The resulting increased demand will ensure remunerative price to the safflower farmers, boosting the area and production of safflower in the country. Moreover, the “high oleic” safflower will also have high export potential and can turn India from a “safflower importing” to “safflower exporting” country in due course. Thus, there will be many beneficiaries of the “high oleic” safflower.

    Scientist in charge: Dr. P. B. Ghorpade (Emeritus scientist)
    SRF: Dr. Santosh Devkar
  • Direct Beta-Thalassemia Carrier Detection Kit under DBT-BIRAC scheme.

    Thalassemia is an autosomal recessive disorder characterized by reduced or absence of one or more of the globin chain of adult haemoglobin. It is an inherited genetic disorder, wherein afflicted child born only when both the parent are carriers. Our innovative idea is to develop a finger prick diagnostic kit for detection of beta thalassemia carrier which is simple, cost effective, efficient, reliable does not require any equipment and can be easily applied in the field. This kit will equip us to provide genetic counseling particularly to the high risk group, to enable them to avoid carrier-carrier marriage and prevent thalassmic child birth in the country

    In charge: Mr. Yogesh S. Badhe (Project assistant)
  • Exploring the Antimetastatic Breast Cancer Potential of the Flax Lignans.

    About 90% breast cancer deaths are due to the metastatic spread. Enterolactone (EL) and enterodiol (ED) the mammalian lignans derived from flax lignan have a very potent anti-metastatic activity in breast cancer. The objective the present study is to investigate molecular and cellular mechanisms to establish the therapeutic value of the flax lignan in reducing breast cancer risk and management of breast cancer by improving prognosis

    In charge: Mr. Aniket Mali (Junior Scientist)
  • Coatings and methods for development of infection-resistant medical devices (In collaboration with Columbia University, New York, USA)
    • Development of antimicrobial latex urinary Foley catheter
    • Development of antimicrobial silicone urinary Foley catheter. There is great demand for effective antimicrobial coating technologies on the surface of medical devices for preventing potential infections. The research objective is to develop a novel antimicrobial coating composition and method of producing affordable, safe and lubricious antimicrobial medical devices, such as urinary catheters, which provide a prolonged and broad spectrum antimicrobial efficacy.
    • In charge scientists: Dr. Arnab Ghosh (Scientist) and Dr. Anand A. Zanwar (Scientist)
  • Cancer program

    Deciphering mechanism of action of various anti-cancer drugs alone or in combination at cell signaling level has been the key focus. Work is being carried out using various cell lines and patient derived clinical samples.
    The evaluation of the utility of the outdated Platelet Concentrate in pre-clinical wound healing models is being done at IRSHA. The clinical evaluation of the same will be done at Bharati Hospital in association with Bharati Blood Bank

    In charge scientist: Ms. Asavari Joshi (Scientist)
  • Clinical evaluation of Omega-3 fortified Chinchadi oil in the management of Amavata (Rheumatoid Arthritis) on the basis of various scientific parameters

    In collaboration with Dr. Vedpathak, Dept. of Panchkarma, college of Ayurveda, BVDU, Pune. The objective is to formulate omega-3-massage oil for Rheumatoid Arthritis using linseed oil and validation of omega-3-fortified massage oil using clinical study based on scientific parameters. This project is designed to study the effect of linseed oil for the management of Rheumatoid Arthritis and thus to find a better and alternative method of treatment for Rheumatoid Arthritis.

    In charge scientist: Dr. Anand A. Zanwar (Scientist)
    Dr. Chethana Bhat (Project assistant)

  • Scale up and commercialize of omega-3 products.
    At present working to scale up and commercialize of following omega-3 products.
  • Manufacturing and marketing of Flaxseed oil emulsion (ALVEL Fortifier) on pilot scale
  • Manufacturing and marketing of Enriched Feed Mix (EFM) for Omega 3 Chicken.

    In charge scientist: Mr. L. L. Panse (Managing Director, Real World Nutrition Laboratory Foundation)

Publications

  • Publications: 57
  • Book chapters: 5
  • Patent applications: 06
  • Books: 04

PhD awarded

  • 02 from IRSHA
  • 15 before joining IRSHA

Current Team

  • Mr. Yogesh Badhe (Project Assistant)
  • Ms. Sunita Bhise (Project Assistant)
  • Dr Chethana Bhat (Project Assistant)

Dr. Anand Zanwar

The main focus includes preclinical pharmacology and toxicology. Evaluating role of medicinal plant in nutrition with special reference to metabolic health. Major focus of research work includes pharmacological and nutritional aspects of flaxseed and omega-3- fatty acid. It includes pharmacological screening with respect to antihyperlipidemic activity, phytochemical analysis, isolation of active constituents by column chromatography of flax lignan and other constituents in flaxseed.

Apart from this various projects related to anti-inflammatory, wound healing, hepatoprotective, diabetes, anti-hypertensive, cardioprotective activity and complication of cardiovascular disease in pre-clinical screening of various medicinal plants/herbal extracts are also being carried out.

Current Research projects

  • ICAR-AICRP- Linseed Value Addition Centre

    AICRP-Linseed Value Addition Centre has been granted to BVDU by ICAR in recognition of excellent work done in two major NAIP projects. It has been shown that linseed value addition can provide better price to the farmer and utilization of high yielding linseed varieties developed by different AICRP centers can promote the linseed agriculture. Value addition in linseed will lead to assured a good price to the linseed growing farmer and also high value health product to the consumer.

    Nutritionally important linseed value added products developed under AICRP-BVDU will result in better returns to linseed growing farmers. The economically viable technologies developed by AICRP-BVDU will be implemented at national level with the help of remaining AICRP centers in the country. These technologies are not only valuable to linseed farmer but also to bakery, dairy, pharmaceutical, neutraceutical and poultry industry importantly for human health.

  • Topical cream containing silversulfadiazine along and in combination with omega-3- fatty acid for topical antimicrobial and wound healing. In collaboration with University of Columbia, New York, US.

    Objective of the investigation is to evaluate of wound healing activity of silver sulfadiazine alone and in combination with omega-3- fatty acid in rats. Method: Excision wound model. Expected outcome: Novel topical formulation containing silver sulfadiazine and omega-3- fatty acid for wound healing with potential antibacterial and anti-inflammatory action.

  • Development of flax seed fortified functional foods In collaboration with ICAR-CIAE- Bhopal.

    Flaxseed seed with its high level of omega-3- fatty acid (ω-3-FA), assumes super food status. It has high nutritional value. Still it is not fully exploited for food fortification. The objective is to optimize and standardize technology of fortification of ground flaxseed in bakery products and to evaluate the effect of processing conditions which are expected to impact flaxseed-enriched products bioactive compounds bio-accessibility, bioavailability, and activity.

Publications

  • International publications: 22
  • Book chapters: 12
  • Patent applications: 02

PhD Awarded: Nil

Current Team

  • Ms. Shital Phalke (M.Pharma.-Project assistant)
  • Mr. Pramod Farde (B.Pharma- Technical assistant)

Collaborations

Dr. Shanta Modak Columbia University, New York, USA.
Dr. Vedpathak Dept. of Panchkarma, college of Ayurveda, BVDU.
Department of Pharmacology Poona college of Pharmacy, BVDU, Pune.
Dr. S. R. Rojatkar R & D Centre in Pharmaceutical Sciences and Applied Chemistry, BVDU, Pune.
Dr. Ravi Kharat and Dr. Deshmukh Department of Surgery, Medical College and hospital, BVDU, Pune.

Dr. Arnab K Ghosh

There is great demand for effective antimicrobial coating technologies on the surface of medical devices for preventing potential infections. My research objective is to develop a novel antimicrobial coating composition and method of producing affordable, safe and lubricious antimicrobial medical devices, such as urinary catheters, which provide a prolonged and broad spectrum antimicrobial efficacy.

Current research projects

Coatings and methods for development of infection-resistant medical devices

  • Development of antimicrobial latex urinary Foley catheter
  • Development of antimicrobial silicone urinary Foley catheter

Publications:09

Dr. P B Ghorpade

  • Participatory Plant Breading, seed production and commercial production of linseed variety PKVNL- 260 in Nagpur, Chandrapur and Wardha with aim to supply genetically pure seed for linseed value addition and buyback guarantee to farmers of Vidarbha.
  • Developing high oleic safflower genotypes through functional genomics

Title: Developing high oleic safflower genotypes through functional genomics

The high oleic safflower genotypes developed through this non-transgenic approach can be brought into cultivation much more quickly than the genotypes developed through transgenic approaches. Such “high oleic” varieties will benefit the Indian oil industry due to cheaper availability of indigenous high oleic safflower, which can reduce the market price of the healthier higholeic safflower oil for use as frying / cooking oil as well as for industrial applications. The resulting increased demand will ensure remunerative price to the safflower farmers, boosting the area and production of safflower in the country. Moreover, the “high oleic” safflower will also have high export potential and can turn India from a “safflower importing” to “safflower exporting” country in due course. Thus, there will be many beneficiaries of the “high oleic” safflower.

PhDs awarded

  • 4 students from PDKV, Akola

Current Team

  • Dr. Santosh Devkar (ICAR-NASF Project)

Mr. M.L. Panse

The current programs of scale up and commercialization are given below :-

  • Manufacturing and marketing of Flaxseed oil emulsion (ALVEL Fortifier) on pilot scale
  • Manufacturing and marketing of Enriched Feed Mix (EFM) for Omega 3 Chicken.

Current Team

  • Real World Nutrition Laboratory Foundation, Pune.

Mrs. Asavari Anirudha Joshi

Deciphering mechanism of action of various anti-cancer drugs alone or in combination at cell signaling level has been the key focus. Work is being carried out using various cell lines and patient derived clinical samples with emphasis on breast cancer and flax lignan.

The evaluation of the utility of the outdated Platelet Concentrate in pre-clinical wound healing models is being done at IRSHA. The clinical evaluation of the same will be done at Bharati Hospital in association with Bharati Blood Bank.

Team Member

  • Mr. Aniket Mali (Junior Research Scientist)
Symposium

2nd David Barker Memorial Symposium on Developmental Origins of Health and Disease (DOHaD) on Saturday 18th February 2017

CME by Ministry of AYUSH

CME on Basic Research Techniques for Ayurvedic PG Teachers Contact: Dr. Supriya Bhalerao - 27th February to 4th March 2017

World Obesity Day

On occasion of World Obesity Day, a workshop on Anthropometric assessment was organized by Obesity Research Lab, IRSHA on 13th October 2016. Dr. Sanjay Juvekar and Dr. Hemangi Lubree from Vadu Rural Health Program (VRHP), an initiative of KEM Hospital delivered a lecture on basic techniques of anthropometry followed by demonstration of the anthropometry assessment on volunteers by their team.

National Ayurveda Day

Ministry of AYUSH has declared Dhanateras to be celebrated as National Ayurveda Day. Prof. M S Baghel (Ex- Chairman, Ayurveda Chair University of Debrecan, Hungary) was the special invitee for the auspicious day. He threw light over the Ayurveda concepts of Diabetes, its consequences and its management. A lecture was delivered by Dr. Jyoti Shirodkar (Ayurvedic Diabetologist, Asso. Prof. Dept of Dravyaguna, TAMV) based on the theme Prevention and Control of diabetes using Ayurveda.

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