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Interactive Research School For Health Affairs (IRSHA), Pune

Obesity-Diabetes

Dr. Supriya Bhalerao

The prevalence of metabolic diseases is increasing worldwide. Obesity forms a cornerstone of these diseases. Further, amongst various comorbidities associated with obesity, diabetes is the most commonly observed condition. While Orlistat is the only anti-obesity drug available in the market currently, the available Oral Anti-Diabetic Agents are associated with range of adverse effects. In addition, another challenge posed by these conditions is unavailability of prevention strategies.On this background, the aim of the Obesity-Diabetes laboratory is to evaluate the efficacy of herbal drugs, nutraceuticals and lifestyle interventions in these conditions and to elucidate their mechanism of action.

Current Research Projects:

  • Effect of Yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals

    Funding agency: Department of Science and Technology- Science and Technology of Yoga and Meditation (DST – SATYAM)

    Yoga is reported to be beneficial in diabetes for control of blood glucose level. However the mechanism through which yoga works on blood glucose level in not known. One of the possible mechanisms can be glucose regulation mediated through skeletal muscles. The present study is therefore planned to evaluate effect of yoga intervention muscle quality/functionality and thereby normalization of glucose levels in pre-diabetic individuals. This would potentially be used as a prevention or prolongation program for a population that shows diabetic symptoms and is at risk of getting diabetes in short time. It would also be useful for a known population (obese population for e.g.) at risk of having diabetes.

  • Evaluation of Triphala and Trimad for their effects on adipocytes biology and lipid metabolism

    Funding agency: Ministry of AYUSH

    Triphala and Trimad are polyherbal combinations recommended in Ayurvedictexts for management of obesity. Although there is anecdotal clinical evidence available to support their efficacy in obesity, their mechanism of action has not been studied so far. The present project is therefore planned to elucidate their effects on adipocytes biology and lipid metabolism in 3T3 fibroblast cell-line model and High Fat Diet induced Obesity model in rats respectively.

  • Evaluation of the effect of Triphala on obesity induced cognitive deficits

    The impairment in neuro-cognitive functioning linked to obesity is an important yet under-emphasized area. In present study we are planning to evaluate the effect of Triphalaand further elucidate its mechanism of action in experimental models of obesity associated cognitive impairments. We are proposing to carry out both in vitro and in vivo studies. While in vitro model resembles the damage to brain cells by increased levels of free fatty acids in obesity, the in vivo model focuses on the behavioral and altered biochemical changes seen in obesity.

  • Predictors of Diabetes in first degree relatives of type II DM individuals: Visceral Fat and Visceral Adiposity Index

    It is well known fact that the First-degree relatives (FDR) of type 2 diabetic patients have considerably increased risk for development of the disease later in life. Being FDR is therefore considered as an important contributory factor to Indian Diabetes Risk Score. The present study is planned to investigate whether abdominal obesity can prove as an additional predictor of diabetes in FDRs of type II DM patients.

  • Risk assessment of Metabolic syndrome using Ayurvedic concept of Prakriti

    In Ayurveda, the concept of Prakriti represents the essence of personalized medicine. It is said that Prakriti of an individual is determined at the time of conception and remains constant throughout the life span of the individual. Prakriti of an individual can be identified on the basis of phenotypic characters like physique, physiological and psychological patterns. The prevalence of specific Prakriti types in various components of Metabolic syndrome (MS) viz. obesity, diabetes and cardiovascular diseases has already been reported. These studies however lack in providing association between Prakriti and MS in absence of Controls and inadequate power of study (sample size). The present project is therefore planned to establish Prakriti as a risk factor for assessment of MS and further to explore the differences in patho-physiological mechanisms of MS in different Prakriti types.

Publications:

  1. Bhoite G, Bulakh P, Kuvalekar A, Momin A. Lipid Profile as a Marker of Cardiovascular Disease in Type 2 Diabetics with and without Nephropathy. SAS J. Med. (2017); 3(4):61-65. (IF:NA)
  2. Bhoite G, Bulakh P, Kuvalekar A, Momin A. Association of Albumin to Creatinine Ratio with Cardiovascular Risk Markers and Determination of Their Cut off Points in Type 2 Diabetic Nephropathy Patients. IOSR Journal of Dental and Medical Sciences. (2017);16(5);63-67. (IF:NA)
  3. Mandave P, Kuvalekar A, Mantri N, Islam M, Ranjekar P. Cloning, Expression and Molecular Modeling of the Anthocyanidin Reductase (FaANR) Gene During Strawberry Fruit Development. Fruits. (2017) ;72(3);139-147. (IF:1.01)
  4. Chavan TC, Ghadge AA, Karandikar MN, Pandit VA, Ranjekar PK, Kulkarni OP, Kuvalekar AA and Mantri NL .Hepatoprotective activity of Sawa, an ayurvedic formulation, from three species of Tinospora against alcohol induced liver injury in rats. AlternTher Health Med. (2017) ;23(4):34-40. (IF:1.5)
  5. Ghadge A and Kuvalekar A. Controversy of Oral Hypoglycemic Agents in Type 2 Diabetes Mellitus: Novel Move towards Combination Therapies. Diabetes and Metabolic Syndrome: Clinical Research & Reviews. (2017).1:S5-S13. (IF: 1.81)
  6. Harke S, Khadke S, Ghadge A, Manglekar A, Shah S, Diwan A, Kuvalekar A. Adipocytokines and anthropometric measures in type 2 diabetics. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. (2017). Suppl1:S273-S276. (IF: 1.81)
  7. Ghadge A, Diwan A, Harsulkar A, Kuvalekar A. Gender dependent effects of glycemic status and disease duration on biochemical markers in type 2 diabetes: A pilot study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. (2017) Suppl 1: S481-S489. (IF: 1.81)
  8. Kaashyap M, Ford R, Bohra A, Kuvalekar A, Mantri N. Improving Salt Tolerance of Chickpea Using Modern Genomics Tools and Molecular Breeding. Curr Genomics. (2017);18(6):557-567. (IF: 2.86)
  9. Diwan A Kuvalekar A, Dharamsi S, Vora A, Nikam V, Ghadge A. Co-relation of serum adiponectin and leptin levels in obesity and type 2 diabetes mellitus. Indian Journal of Endocrinology and Metabolism. (2018) ; 22:93-99. (IF: 1.78)
  10. Ghadge A, Khaire A, Kuvalekar A. Adiponectin: A potential therapeutic target for metabolic syndrome. Cytokine & Growth Factor Reviews. (2018);39: 151-58. (IF: 7.13)
  11. Banjare J, Raina P, Mansara P, Ghanekar RK, Bhalerao S. Triphala, regulates adipogenesis through modulation of expression of adipogenic genes in 3T3-L1 Cell line. Phcog Mag (2017);13, Suppl S4:834-9
  12. Banjare J, Salunke M, Indapurkar K, Ghate U, Bhalerao S. Estimation of serum malondialdehyde as a marker of lipid peroxidation in medical students undergoing examination-induced psychological stress. J SciSoc (2017); 44:137-9
  13. Salunke M, Deshpande M, Bhalerao S, Experiential documentation of Trimad for its anti-obesity potential: A survey of Ayurvedic physicians from Pune city, J Ayurveda Integr Med (2017); 8, 190-193
  14. Madhavi Mahajan, Sneha Kulkarni, Veena Deo, Bharatbhushan Shrikhande and Supriya Bhalerao. Capsule Ibomic a Polyherbal Formulation for the Treatment of Irritable Bowel Syndrome Type - D: A Case Series. (2017) Int J Ayu Pharm Chem 7(1):103-110
  15. Salunke Megha, Giramkar Shital, Bhalerao Supriya. In vitro free radical scavenging potential of Trimad (A Polyherbal Formulation), Int. J. Res. Ayurveda Pharm. (2017). 8 (3),:127-131

Industry projects:

Our lab is rigorously involved in industry sponsored clinical trials in all research areas

Current Team:

  • Dr. Poonam Gupte, Senior Research Assistant
  • Dr. Abhijit Ghadge, Research Assistant
  • Dr. Sarika Mane, Research Assistant
  • Ms. Shital Giramkar, Technical Assistant
  • Ms. Shubhangi Harke, AYUSH JRF
  • Ms. Megha Salunke, PhD student
  • Mr. Suresh Khadke, PhD student (Guide: Dr. Aniket Kuvalekar)










Tender Notice

Notice inviting tenders from competent and experienced vendors for
1.Multicolour flowcytometer
2.ELISpot scanner cum Plaque counter
3.Real time PCR System
4.Multiplex protein array system
Submission date extended to 26.08.2019

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