Details

Dr. Deepali Sundrani

Profile

Profile

Date of Birth: 07/11/1985

Qualification: M.Sc. Ph.D (Biotechnology)

Designation: Assistant Professor

Contacts

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Phone: 020-24366920 (ext.312)

Research experience: 6 years

Area of interest: Mother and Child Health, Epigenetics, Placental Nutrient Transport

Honors/Awards

  • Best Poster Presentation at the 19th Annual SNEHA-MRC International workshop on Developmental Origins of Health and Diseases (DOHaD), Hyderabad, 26th – 28th February, 2016.
  • Prof. N. R. Moudgal Young Scientist Award-2016 at the 26th Annual Meeting of the Indian Society for the Study of Reproduction and Fertility (ISSRF) along with International Conference on Reproductive Health with Emphasis on Occupational, Environmental & Lifestyle Factors (ISSRF-2016), 18th – 20th February, 2016, at NIOH, Ahmedabad for outstanding contributions in the field of Reproductive Health.
  • The “Ramanathan Prize” for the best oral presentation in the Free Communication session at the 45th National Conference of the Nutrition Society of India, Hyderabad 21st – 22nd November 2013.
  • The “Young Scientist Award” at the 44th National Conference of the Nutrition Society of India, Tirupati 16th – 17th November, 2012.
  • 2013-2014: Senior Research Fellowship from Indian Council of Medical Research, Govt. of India
  • 2014-2016: Research Associateship from Indian Council of Medical Research, Govt. of India

Invited Talks

  • Delivered a talk on "Understanding Placental Biology in Pregnancy Complications" in the Young Minds Speak session at the "Provocative Ideas on Human Placental Research" meeting scheduled on December 1st – 2nd, 2015 at Translational Health Science and Technology Institute (THSTI), NCR Biotech Science Cluster, Faridabad, India.
  • Delivered a lecture on "Nutrigenomics for a Healthy Future: Recent Developments" at the "International Conference on “Enhancing Health, Wellbeing and Sustainablity-Opportunities, Challenges and Future Directions" on 11th January 2013 held at College of Home Science, Nirmala Niketan, Mumbai.

Professional memberships

  • Life membership of Nutrition Society of India
  • Life membership of Indian Society for the Study of Reproduction & Fertility

Publications:

  • Publications: 25
  • Book Chapters: 03

Research Programmes

Maternal nutrition plays a critical role in fetal development and determines the health of the offspring in early and later life. Human epidemiological studies have shown that alterations in key developmental processes in utero can predispose the offspring to many late-onset diseases. The placenta responds to perturbations in the maternal compartment, such as altered nutrition and reduced utero-placental blood flow thereby, playing a key role in programming the fetus to diseases. These programmed changes are likely to be a result of stable changes in the gene expression patterns which are influenced by epigenetic modifications. Epigenetics is the study of changes in gene expression without any alterations in the underlying nucleotide sequence. Understanding the influence of epigenetic mechanisms in adverse pregnancy outcomes like preterm birth, preeclampsia and low birth weight is my focus area of research. Further my research also focuses on studying the role of maternal nutrients particularly folate, vitamin B12 and polyunsaturated fatty acids in influencing the placental epigenetic patterns during pregnancy.

Publications

  1. Juhi Nema, Deepali Sundrani, Sadhana Joshi. Prenatal Vitamin D Supplementation Reduces Blood Pressure and Improves Placental Angiogenesis in an Animal Model of Preeclampsia. Food & Function (IF:4.171) (In press).
  2. Wadhwani NS, Sundrani DP, Wagh GN, Mehendale SS, Tipnis MM, Joshi PC, Kinare AS, Lalwani SK, Mani NS, Chandhiok N, Chandak GR, Gupte SA, Fall CHD, Joshi SR. The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol. BMC Pregnancy Childbirth. 2019 Aug 23;19(1):308.
  3. Sahay AS, Jadhav AT, Sundrani DP, Wagh GN, Joshi SR. Differential Expression of Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF) in Different Regions of Normal and Preeclampsia Placentae. Clin Exp Hypertens. 2019 Sep 14:1-5.
  4. Kasture V, Sundrani D, Dalvi S, Swamy M, Kale A, Joshi S. Maternal omega-3 fatty acids and vitamin E improve placental angiogenesis in late-onset but not early-onset preeclampsia. Mol Cell Biochem. 2019 Nov;461(1-2):159-170.
  5. Nema J, Sundrani D, Joshi S. Role of vitamin D in influencing angiogenesis in preeclampsia. Hypertens Pregnancy. 2019 Jul 24:1-7.
  6. Kasture V, Sundrani D, Joshi S. Maternal one carbon metabolism through increased oxidative stress and disturbed angiogenesis can disturb placental angiogenesis in preeclampsia. Life Sci. 2018 Aug 1;206:61-69. (IF: 2.93)
  7. Sahay A, Jadhav A, Sundrani D, Wagh G, Mehendale A, Joshi S. Matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9) are differentially expressed in different regions of normal and preeclampsia placentae. J Cell Biochem. 2018 Aug;119(8):6657-6664. (IF: 3.085)
  8. Sahay A, Jadhav A, Sundrani D, Wagh G, Mehendale S, Chavan-Gautam P, Joshi S. VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae. Molecular and Cellular Biochemistry 2017 (In Press)
  9. Khot V, Yadav D, Shrestha S, Kaur L, Sundrani D, Chavan-Gautam P, Mehendale S, Chandak G, Joshi S. Hypermethylated CpG sites in the MTR Gene Promoter in Preterm Placenta. Epigenomics (2017)
  10. Sundrani D, Roy S, Jadhav A, Joshi S. Sex-Specific Differences and Developmental Programming for Diseases in Later Life. Reproduction, Fertility and Development (2017)
  11. Sahay A, Sundrani D, Joshi S. Regional changes of placental vascularization in preeclampsia: A review. IUBMB Life 2015; 67:619-25.
  12. Sahay A, Sundrani D, Wagh G, Mehendale S, Joshi S. Neurotrophin levels in different regions of the placenta and their association with birth outcome and blood pressure. Placenta 2015; 36:938-43.
  13. Meher A, Sundrani D, Joshi S. Maternal nutrition influences angiogenesis in the placenta through peroxisome proliferator activated receptors: A novel hypothesis. Mol Reprod Dev 2015; 82:726-34.
  14. Sahay A, Sundrani D, Wagh G, Mehendale S, Joshi S. Regional differences in the placental levels of oxidative stress markers in pre-eclampsia. Int J Gynaecol Obstet 2015; 129:213-8.
  15. Sundrani D, Reddy U, Chavan-Gautam P, Mehendale S, Chandak G, Joshi S. Altered methylation and expression patterns of genes regulating placental angiogenesis in preterm pregnancy. Reprod Sci 2014; 21:1508-17.
  16. Sahay A, Patil V, Sundrani D, Joshi A, Wagh G, Gupte S, Joshi S. A longitudinal study of circulating angiogenic, anti-angiogenic factors and AT1-AA levels in preeclampsia. Hypertens Res 2014; 37:753-8.
  17. Sundrani D, Reddy U, Joshi A, Mehendale S, Chavan-Gautam P, Hardikar A, Chandak G, Joshi S. Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preclampsia. Clin Epigenetics 2013; 5:6.
  18. Sundrani D, Chavan Gautam P, Pisal H, Mehendale S, Joshi S. Placental levels of matrix metalloproteinase-2, -3 and tissue inhibitors of metalloproteinases – 1, -2 in preterm pregnancy. Reproduction 2013; 145:401-10.
  19. Sundrani D, Khot V, Pisal H, Mehendale S, Wagh G, Joshi A, Joshi S. Gestation dependant changes in angiogenic factors and their associations with fetal growth measures in normotensive pregnancy. PLoS One 2013; 8:e54153.
  20. Sundrani D, Chavan Gautam P, Pisal H, Mehendale S, Joshi S. Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy. PLoS One 2012; 7:e29855.
  21. Sundrani D, Chavan Gautam P, Mehendale S, Joshi S. Altered metabolism of maternal micronutrients and omega 3 fatty acids epigenetically regulate matrix metalloproteinases in preterm pregnancy: A novel hypothesis. Med Hypotheses 2011; 77:878-83.
  22. Sundrani D, Chavan-Gautam P, Pisal H, Nimbargi V, Mehendale S, Joshi S. Gestation-dependent changes in human placental global DNA methylation levels. Mol Reprod Dev 2011; 78:150.
  23. Sundrani D, Narang A, Mehendale S, Joshi S, Chavan-Gautam P. Investigating the expression of MMPs and TIMPs in preterm placenta and role of CpG methylation in regulating MMP-9 expression. IUBMB Life 2017 Nov 11. doi: 10.1002/iub.1687.
  24. Kemse N, Sundrani D, Kale A, Joshi S. Maternal micronutrients, omega-3 fatty acids and gene expression of angiogenic and inflammatory markers in pregnancy induced hypertension rats. Arch Med Res. 2017 Jul;48(5):414-422. (IF: ‎2.71)

Book Chapters

  1. Kinjal Dave, Deepali Sundrani, Sadhana Joshi. Influence of nutrition on reproductive health through epigenetic mechanisms Elsevier, 2019
  2. Sahay A, Sundrani D, Joshi S (2016). Neurotrophins: Role in placental growth and development. Neurotrophins. Edited by Dr. Gerald Litwack. (Published by Elsevier).
  3. Sundrani D, Khot V, Joshi S (2015). DNA methylation for prediction of adverse pregnancy outcome. Chapter 18. Section 3, Epigenetic Biomarkers and Clinical Applications. Volume, Epigenetic Biomarkers and Diagnostics. Series, Translational Epigenetics. Edited by Dr. Jose Luis Garcia-Gimenez. Pg no 351-376. (Published by Elsevier).