Designation: Associate Professor and Head, Cancer Research Lab
Phone: 020-24366920 (ext.202)
Associate Professor, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India (2007 – till date)
Scientist “C” in Nanobiotechnolgy Division at Agharkar Research Institute, (Department of Science and Technology (DST), Govt. of India Institute (2006-07)
Research Associate at Nanobiotechnolgy Division at Agharkar Research Institute, (Department of Science and Technology (DST), Govt. of India Institute (2005-06)
DBT-Post Doctoral Research Fellow at Department of Biotechnology, Pune University, India (2004-05)
Teaching/Research Associate at Department of Biotechnology, Pune University, India (2003-04)
Area of interest:
Cancer Biology, Cell and Molecular Biology, Protein Biochemistry
Bharati Vidyapeeth’s “Best Researcher Award”, April 2011 for research excellence
Scientific Advisory Committee (SAC) member of CCRUM (Center Council of Research for Unani Medicine), Ministry of AYUSH, Govt of India.
Chairman for Nanobiology subject of MTech Nanotechnology, College of Engineering, Bharati Vidyapeeth (Deemed to be University), Pune
Registered Ph.D. guide for Biotechnology, Bharati Vidyapeeth (Deemed to be University), Pune, India
Chairman for Nanobiology subject of MTech Nanotechnology, College of Engineering, Bharati Vidyapeeth (Deemed to be University), Pune
Reviewer for many peer reviewed journals
Member, Society for Ethnopharmacology- India, Pune Chapter
Life Member of Indian Society for Developmental Biologists (ISDB)
Varsha Shetty, Alok Jakhade, Kavita Shinde, Rajeev Chikate and Ruchika Kaul-Ghanekar. Folate mediated targeted delivery of Cinnamaldehyde loaded and FITC functionalized magnetic nanoparticles in breast cancer: in vitro, in vivo and pharmacokinetic studies. New J. Chem., 2020
Madhura A. Damle, Varsha G. Shetty, Alok P. Jakhade, Ruchika Kaul-Ghanekar and Rajeev C. Chikate. Bi-functional nature of nanoceria: pro-drug and drug-carrier potentiality towards receptor-mediated targeting of doxorubicin. New J. Chem., 2020,44, 17013-170
Varsha Shetty, Bothiraja, Chellampillai, Ruchika Kaul-Ghanekar. Development and validation of bioanalytical HPLC method for simultaneous estimation of cinnamaldehyde and cinnamic acid in rat plasma: Application for pharmacokinetic studies. New Journal of Chemistry, 2020, DOI: 10.1039/C9NJ03183A
Snehal Suryavanshi, Kavita Shinde, Prerna Raina, Ruchika Kaul-Ghanekar. Tumor Retardation and Immunomodulatory potential of Polyherbal Formulation HC9 in Mouse Melanoma Model. Pharmacognosy Magazine. 2020
Ekta Gupta, Ruchika Kaul-Ghanekar , SS Manhas , Arun Bhargav. Evaluating the Anticancer Activity of Homoeopathic Preparation of Asterias rubens in Breast Cancer Cell Line on the Basis of Similia Principle. International Journal of Health Sciences and Research.10, 2020
Snehal Suryavanshi, Amit Choudhari, Prerna Raina, Ruchika Kaul-Ghanekar. A polyherbal formulation, HC9 regulated cell growth and expression of cell cycle and chromatin modulatory proteins in breast cancer cell lines. J Ethnopharmacology. 2019; 242:112022
Ghazala Mulla, Sufyan Ahmed Ghawte, Prerna Raina and Ruchika Kaul-Ghanekar. Treatment of recurrent breast abscess by cupping therapy and raw papaya paste dressing: A case report. International Journal of Unani and Integrative Medicine 2019; 3(3): 01-08
Rashmi Deshpande, Prerna Raina, Kavita Shinde, Prakash Mansara, Manjiri Karandikar and Ruchika Kaul-Ghanekar. Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer. 2019. Prostaglandins and Other Lipid Mediators 143, 106332.
Jyotibala Banjare, Prerna Raina, Prakash Mansara, Ruchika Kaul Ghanekar, Supriya Bhalerao. Triphala, Regulates Adipogenesis Through Modulation of Expression of Adipogenic Genes in 3T3-L1 Cell Line. Pharmacogn Mag. 2018 Jan;13(Suppl 4):S834-S839.
Ashwini Kamble, Varsha Shetty, S. M. Shendokar, S. S. Chavan and Ruchika Kaul-Ghanekar. Synthesis, characterization and antibacterial activity of ciprofloxacin loaded electrospun gelatin nanofibers 2018 J Bionanosci. 12, 732–737.
Shama Aphale, Savita Pandita, Prerna Raina, J.N Mishra, Ruchika Kaul-Ghanekar. Phytochemical Standardization of Panchvalkala, an Ayurvedic Formulation and Evaluation of its Anticancer Activity in Cervical Cancer Cell Lines. 2018. Pharmacognosy Magazine, 14: 554-560
P Raina, B Bharathi, A Senthilkumar, S Sagar, CV Chandrasekaran, D Prabhu, M Deepak, A Amit, R Kaul-Ghanekar. Effect of aqueous/methanolic extract of Ocimum sanctum (OciBest) on the Male and Female reproductive performance of wistar rats. 2018. Pharmacognosy Magazine, 14: 256-263.
Kadu, B.S., Wani, K.D., Kaul-Ghanekar, R. and Chikate, R.C. Degradation of doxorubicin to non-toxic metabolites using Fe-Ni bimetallic nanoparticles. 2017. Chemical Engineering Journal.
Srinu Meesala, Vijay Lakwal, Dinesh Kharate, Satish Mokashe, Prerna Raina, Ruchika Kaul- G, Milind Watve (2017) Oxazoles from marine sponge Mycale (Zygomycale) parishii. International Journal of Scientific Research, 6(5):216-218.
Patil M, Choudhari A, Pandita S, Islam MA, Raina P, Kaul-Ghanekar R. Cinnamaldehyde, cinnamic acid and cinnamyl alcohol, the bioactives of Cinnamon cassia exhibit HDAC8 inhibitory activity-an in vitro and in silico study. 2017. Pharmacognosy Magazine (in press)
Suryavanshi S, Raina P, Deshpande R, Kaul-Ghanekar R. Nardostachys jatamansi root extract modulates the growth of IMR-32 and SK-N-MC neuroblastoma cell lines through MYCN mediated regulation of MDM2 and p53.. Pharmacognosy Magazine 2017, 13: 21-24.
Kirtee Wani, Nilesh Shah, Asmita Prabhune, Arun Jadhav, Prabhakar Ranjekar and Ruchika Kaul-Ghanekar. Evaluating the anticancer activity and nanoparticulate nature of homeopathic preparations of Terminalia chebula (TC). Homeopathy, 2016, 105: 318-326
Parul Dubey, Prerna Raina, Asmita Prabhune and Ruchika Kaul-Ghanekar. Cetyl alcohol and oleic acid sophorolipids exhibit anticancer activity. (Accepted in International Journal of Pharmacy and Pharmaceutical Sciences, 2016).
Prerna Raina, Deepak M, Chandrasekaran CV, Amit Agarwal, Narendra Wagh and Ruchika Kaul-Ghanekar. Comparative analysis of anti-inflammatory activity of aqueous and methanolic extracts of Ocimum basilicum in RAW264.7, SW1353 and human primary chondrocytes. Accepted in Journal of Herbal Medicine, 2016
P Raina, CV Chandrasekaran, M Deepak , A Aggarwal and K-G Ruchika. Evaluation of subacute toxicity of methanolic/aqueous preparation of aerial parts of O.sanctum in Wistar rats: clinical, hematological, biochemical and histopathological studies. J Ethnopharmacol. 2015 Dec; 175:509-17.
Rashmi Deshpande, Prakash Mansara and Ruchika Kaul-Ghanekar. Alpha linolenic acid regulates Cox2/VEGF/MAP kinase pathway and decreases the expression of HPV oncoproteins E6/E7 through restoration of p53 and Rb expressionin human cervical cancer cell lines Tumour Biol. 2015 Oct 6.
Prerna Raina, CV Chandrasekaran, Amit Aggarwal, Narendra Wagh and Ruchika Kaul-Ghanekar. Comparative analysis of anti-inflammatory activity of aqueous and methanolic extracts of C. cassia and C. zeylanicum in RAW264.7, SW1353 and primary chondrocytes. International Journal of Pharmacy and Pharmaceutical Sciences, 7: 392-396, 2015.
Snehal A Suryavanshi, Kavita Shinde-Kadam, Prerna Raina, Ravindra Nimbargi, Vijaya A Pandit and Ruchika Kaul-Ghanekar. Evaluation of acute and sub-acute toxicity of a standardized polyherbal formulation (HC9): an in vivo study. International Journal of Pharmacy and Pharmaceutical Sciences, 7:110-117, 2015.
Prakash P. Mansara, Rashmi A. Deshpande, Milind M. Vaidya, Ruchika Kaul-Ghanekar. Differential ratios of omega fatty acids (AA/EPA+DHA) modulate growth, lipid peroxidation and expression of tumor regulatory MARBPs in breast cancer cell lines MCF7 and MDA-MB-231. PlosOne, 10(9):e0136542, 2015.
Kirtee Wani, Kirtan Tarawadi and Ruchika Kaul-Ghanekar. Nanocarriers for delivery of herbal based drugs in breast cancer-an overview. Journal of Nano Research 34: 29-40, 2015.
Prakash Mansara, Mrunal Ketkar, Rashmi Deshpande, Amol Chaudhary, Kavita Shinde, Ruchika Kaul-Ghanekar. Omega-3 fatty acid supplementation in breast cancer patients undergoing chemotherapy improved their antioxidant status - a case series. J Med Case Reports, 9:148, 2015.
Pradeep Kumar Singha, Kirtee Wani, Ruchika Kaul-Ghanekar, Asmita Prabhune and Satishchandra Ogale. From Micron to Nano-Curcumin by sophorolipid co-processing: Highly enhanced bioavailability, fluorescence, and anti-cancer efficacy. RSC Advances, 4: 60334-41, 2014.
Kirtee D. Wani, Brijesh S. Kadu, Preeti Gupta, Avinash V. Deore, Rajeev C. Chikate, Pankaj Poddar, Sanjay D. Dhole and Ruchika Kaul-Ghanekar*. Synthesis, characterization and in vitro study of biocompatible Cinnamaldehyde functionalized magnetite nanoparticles (CPGF NPs) for hyperthermia and drug delivery applications in breast cancer. PlosOne, 9: e107315; 2014
Snehal Suryavanshi, Anand Zanwar, Mahabaleshwar Hegde and Ruchika Kaul-Ghanekar*. Standardization of a polyherbal formulation (HC9) and comparative analysis of its cytotoxic activity with respect to the individual herbs present in the composition in breast cancer cell lines. Pharmacognosy Journal 6: 87-95, 2014.
Amit S Choudhari, Prerna Raina, Manasi M Deshpande, Ashok G Wali, Anand Zanwar, Subhash L Bodhankar, Ruchika Kaul-Ghanekar*. Evaluating the anti-inflammatory potential of Tectaria cicutaria L. rhizome extract in vitro as well as in vivo. Journal of Ethnopharmacology 150 215–222, 2013.
Amit S. Choudhari, Snehal A. Suryavanshi and Ruchika Kaul-Ghanekar*. The aqueous extract of Ficus religiosa induces cycle arrest in human cervical cancer cell lines SiHa (HPV-16 positive) and apoptosis in HeLa (HPV-18 positive). 2013. PlosOne [The abstract of paper was featured in World Biomedical Frontiers (http://biomedfrontiers.org/cancer-2014-5-7/ ].
Synthesis and characterization of gold nanoparticles using Ficus religiosa extract. Kirtee Wani, Amit Choudhari, Rajeev Chikate and Ruchika Kaul-Ghanekar*. 2013. Carbon – Sci. Tech. 5/1 (2013) 203 - 210
Rashmi Deshpande, Prakash Mansara, Snehal Suryavanshi, Ruchika Kaul-Ghanekar*. Alpha-linolenic acid regulates the growth of breast and cervical cancer cell lines through regulation of NO release and induction of lipid peroxidation. 2013. Journal of Molecular Biochemistry.
Ruchika Kaul-Ghanekar*, Prerna Raina. Potential of Nutraceuticals and Medicinal Plants in the Management of Osteoarthritis. Review. Acta Biologica Indica 2012,1(1):27-46.
Mithun Bandivadekar, Shyamsundar Pancholi, Ruchika Kaul-Ghanekar, Amit Choudhari, and Soumya Koppikar. Single non-ionic surfactant based self-nanoemulsifying drug delivery systems: formulation, characterization, cytotoxicity and permeability enhancement study. Drug Development and Industrial Pharmacy, 2012; Early Online: 1–8
Kale S, Jadhav A, Verma S, Koppikar S, Kaul-Ghanekar R, Dhole S, Ogale S. 2011. Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery. Nanomedicine 2012 May;8(4):452-9. Epub 2011 Aug 10.
Amit Subhash Choudhari, Snehal Suryavanshi, Harshad Ingle, Ruchika Kaul-Ghanekar*. Evaluating the antioxidant potential of aqueous and alcoholic extracts of Ficus religiosa using ORAC assay and assessing their cytotoxic activity in cervical cancer cell lines. Biotechnol. Bioinf. Bioeng. 2011, 1(4):443-450
Snehal Suryavanshi, Amit Choudhari, Rucha Deshpande, Omkar Kulkarni, Ruchika Kaul-Ghanekar*. Analyzing the antioxidant potential of aqueous and ethanolic preparations of a herbal composition (HC9) and evaluating their cytotoxic activity in breast cancer cell lines. Biotechnol. Bioinf. Bioeng. 2011, 1(4):513-522
Wani K, Ahmed A, Kitture R, Koppikar S, Choudhari A, Kale S, Kaul-Ghanekar R*. Synthesis, characterization and in vitro study of curcumin-functionalized citric acid-capped magnetic (CCF) nanoparticles as drug delivery agents in cancer. Journal of Bionanoscience Vol. 5, 59–65, 2011.
Bandivadeka MM, Pancholi SS, Kaul-Ghanekar R, Choudhari A, Koppikar S. Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug. Drug Dev Ind Pharm. 2011 Nov 16.
Malonia SK, Sinha S, Laksminarsimhan P, Singh K, Jalota Badhwara, Rampalli S, Kaul-Ghanekar R & Chattopadhay S. Gene regulation by SMARI: Role in cellular homeostasis & cancer, Biochim Biophys Acta. 2011 Jan;1815(1):1-12. Epub 2010 Aug 13. Review.
Kittur A, Koppikar S, Kaul-Ghanekar R & Kale S. N. Catalyst efficiency, photostability & reusability study of ZnO nanoparticles in visible height for dye degradation. Journal of Physics & Chemistry of Solids, 2011, 72(1): 60-66.
Koppikar S, Choudhari A, Suryawanshi S, Kumari S, Chattopadhay S and Kaul-Ghanekar R*. Aqueous Cinnamon extract (ACE-c) from bark of Cinnamomum cassia causes apoptosis through loss of mitochondrial membrane potential. BMC Cancer 2010; 10: 210.
Singh R, Koppikar S, Paul P, Gilda S, Paradkar AR and Kaul-Ghanekar R*. Comparative Analysis of Cytotoxic Effect of Aqueous Cinnamon Extract (ACE) from Cinnamomum zeylanicum Bark with Commercial Cinnamaldehyde on Various Cell lines. Pharmaceutical Biology (2009); 47: 1174-1179.
Kaul-Ghanekar R, Singh S, Mamgain H, Jalota-Badhwar A, Paknikar KM and Chattopadhyay S. Tumor suppressor protein SMAR1 modulates the roughness of cell surface: combined AFM and SEM study. BMC Cancer 2009, 9:350
Pandey, V., M. V. Vijayakumar, Kaul-Ghanekar R, Mamgain H, Paknikar KM and Bhat MK. Atomic Force Microscopy, biochemical analysis of 3T3-L1 cells differentiated in the absence and presence of insulin. Biochim Biophys Acta. 2009,1790:57-64.
Kale S N, Kitture R, Koppikar S J, Kaul-Ghanekar R, Patil S I. Role Of Zno Bulk And Nanopowders in Photocatalytic Decolorisation of Textile Industrial Dyes. The Abdus Salam International Centre For Theoretical Physics, 2009
Dipak Maity, Sangeeta Kale, Ruchika Kaul-Ghanekar, Jun-Min Xue, Jun Ding. Studies of magnetite nanoparticles synthesized by thermal decomposition of iron (III) acetylacetonate in tri(ethylene glycol). Journal of Magnetism and Magnetic Materials (2009); 321: 3093-3098.
Sandip Dhobale, Trupti Thite, Soumya J. Koppikar, S. L. Laware, Ruchika-Kaul Ghanekar and S. N. Kale. Zinc Oxide Nanorods as alpha-amylase Inhibitors. Journal of Applied Physics (2008); 104: 0949071-5.
K R Bhayani, S N Kale, Sumit Arora, Rajashree Rajagopal, H Mamgain, R Kaul-Ghanekar, Darshan C Kundaliya, S D Kulakarni, Renu Parischa, s D Dhole, S B Ogale and K M Paknikar. Protein and polymer immobilized La0.7Sr0.3MnO3 nanoparticles for possible biomedical applications. Nanotechnology (2007); 18:345101-7.
Jalota-Badhwar A, Kaul-Ghanekar R, Mogare D, Ramanmurthy, B, Paknikar K M and Chattopadhyay S. SMAR1 derived P44 peptide retains its tumor suppressor function through modulation of p53. J Biol Chem. 2007; 282 (13):9902-9913
Kaul-Ghanekar R, Majumdar S, Jalota A, Gulati N, Dubey N, Saha B and Chattopadhyay S. Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1 transgenic mice. J Biol Chem. 2005; 280(10):9450-9.
Kaul-Ghanekar R, Jalota A, Pavithra L, Tucker P and Chattopadhyay S. SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta). Nucleic Acids Res. 2004; 32(16):4862-75.
Kaul R, Mukherjee S, Ahmed F, Bhat MK, Chhipa R, Galande S and Chattopadhyay S. Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice. Int J Cancer. 2003; 103(5): 606-15.(Cover page article)
Sarkar A, Chattopadhyay S, Kaul R, and Pal JK. Lead exposure and heat shock inhibit cell proliferation in human HeLa and K562 cells by inducing expression and activity of the heme-regulated eIF-2alpha kinase. J Biochem Mol Biol Biophys. 2002; 6(6): 391-6.
Chattopadhyay S, Kaul R, Charest A, Housman D and Chen J. SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus. Genomics. 2000; 68(1): 93-6.
Book Chapters: 4
Ruchika Kaul-Ghanekar*, Snehal Suryavanshi, Prerna Raina. Early biomarkers in breast cancer in Cancer Biomarkers: Minimal and Non-Invasive Early Diagnosis and Prognosis. Taylor & Francis, 2014
Ruchika Kaul-Ghanekar*, Amit S Choudhari, Savita Pandita. Biomarkers for Early Detection of Cervical Cancer in Noninvasive Molecular Markers in Gynecologic Cancers. Taylor & Francis, 2015
Ruchika Kaul-Ghanekar*, Snehal Suryavanshi, Prerna Raina. Early biomarkers in breast cancer in Noninvasive Molecular Markers in Gynecologic Cancers. Taylor & Francis, 2015
Savita Pandita, Rashmi Deshpande, Shama Aphale, and Ruchika KaulGhanekar. Role of Medicinal Plants in Targeting Important Signaling Pathways in Cervical Cancer in Holistic Healthcare Possibilities and Challenges, Apple Academic Press, USA, 2016.
General Articles: 5
Snehal A Suryavanshi and Ruchika Kaul-Ghanekar*. Current Scenario of Breast Cancer: An Overview. Bharati Vidyapeeth Deemed University Journal,2013, 10 (3): 16-29.
Amit S Choudhari and Ruchika Kaul-Ghanekar*. Cervical cancer Statistics and prevention Strategies: A special emphasis on Indian scenario. Bharati Vidyapeeth Deemed University Journal,2013, 10 (3): 96-103.
Kirtee Wani and Ruchika Kaul-Ghanekar*. Magnetic iron oxide nanoparticles: Role in cancer. Bharati Vidyapeeth Deemed University Journal,2013, 10 (2): 17-23.
Mansara P, Deshpande R, Kaul-Ghanekar R*, Ranjekar P. Role of Omega 3 fatty acids in the prevention of breast cancer: in vitro, in vivo and clinical studies. Bharati Vidyapeeth Deemed University Journal,2011, 9 (1): 10-18.
Koppikar S J, Harsulkar A, Kaul-Ghanekar R, Ranjekar P. “Exploring an anti-inflammatory potential of medicinal plants in osteoarthritis” Bharati Vidyapeeth Deemed University Journal, 2010,7(2):68-71.