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Interactive Research School For Health Affairs (IRSHA), Pune

Diabetes

Dr. Aniket Kuvalekar

Major focus of research under diabetes program is to study the long-term effects of antidiabetic drugs, visceral obesity as well as lifestyle on lipid imbalance in type 2 diabetes mellitus and its relation with endocrine dysfunction of adipose tissue and occurrence of dyslipidemia. The mechanism of action of time-tested ayurvedic and herbal medicine as well as the neutraceuticals is studied by interventional studies in animal models.

The program also has a societal approach which concentrates on generating awareness about type 2 diabetes mellitus by delivering awareness lectures at colleges and different communities. An effort is specifically made through these lecture to impress the importance of the preventive measures towards type 2 diabetes mellitus.

Current Research projects

  • Project 1

    Title: Effects of antidiabetic drugs, visceral obesity and lifestyle on lipid imbalance in type 2 diabetes mellitus and its relation with endocrine dysfunction of adipose tissue and occurrence of dyslipidemia

    T2DM with uncontrolled hyperglycemia is associated with decreased life expectancy and number of other associated complications like higher rates of hospitalizations, cardiovascular diseases and lipid abnormalities (Melmed et al., 2011). The lipid abnormalities are frequently observed in T2DM patients and imbalance in lipid levels leads to different cardiovascular diseases. With the high number of patients with T2DM at Bharati Vidyapeeth Hospital, the disorder was selected for further research at BVDU IRSHA.

  • Project 2

    Title: Biochemical and Molecular Studies in Type 2 Diabetes Mellitus and Effect of Nutritional Interventions in Animal Models

    The studies on adipocytokines (adiponectin, leptin, resistin, TNF-α) have revealed their consistent association in metabolic syndromes, especially T2DM. But protective effect of adiponectin in diabetes, its association with other markers like leptin, TNF-α and proinsulin (a marker of beta-cell dysfunction) are very poorly studied in Asian-Indian phenotypes. Most of the Indian studies are reported from south (Yajnik et al., 2009; Mohan et al., 2011; Gupta et al., 2012) and a few from North India (Ramachandran et al., 2006; Vipin Gupta et al., 2010) but studies from western India are fragmentary. The present study is aimed at evaluating the associations of different markers (glucose, glycated hemoglobin, liver function test, renal function test, oxidative stress markers, inflammatory markers, lipid profiling, insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) etc.) at biochemical and molecular level in diabetic men and women. The study is also being done on nicotinamide-streptozotocin induced diabetic rat models to study the effects of omega 3 fatty acid interventions.

  • Project 3

    Title: Modulation of pathophysiology of hepatotoxicity with nutritional and herbal interventions in animal models

    Approximately 4 million people in India suffer every year from some form of hepatic damage (Dienstag et al., 1996). Among all human organ toxicities, hepatotoxicity and cardiovascular toxicity are the two most prominent causes, accounting for two out of three market withdrawals (Schuster et al., 2005). Overdose of paracetamol is known to be hepatotoxic and nephrotoxic to man and experimental animals (Pirmohamed et al., 1996) causing necrosis of the centrilobular cells of the liver when taken in overdose (Bessems and Vermeulen, 2001; James et al., 2003a). Paracetamol is a direct hepatotoxin i.e. intoxication is dose dependent and reproducible (Neils et al., 1996). Alcoholic liver disease is second most common reason for liver transplantation in USA (Mandayam, Jamal et al., 2004). The present study aims to study the effects of ayurvedic formulation, guduchi satwa, on chemical-induced hepatotoxicity which is manifested by different types of injury, depending on the nature and dose of the chemical. Paracetamol and ethanol are selected as heptotoxins in the present study.

  • Project 4

    Title: Studies on Flavonoid Biosynthesis During Strawberry Development and its Nutraceutical Potential

    Strawberry is a model plant for studying non-climacteric fruits. Gene expression pattern of flavonoid biosynthesis genes during fruit development is not known in Indian cultivars. Biochemical analysis/variation during progressive developmental stages of fruits is yet to be unraveled. Although there are several articles reporting potential health benefits of flavonoids, there are very few articles which specifically describe the effect of flavonoids on diabetes and hepatotoxicity. The present study is aimed at analyzing the biochemical changes and changes in the expressions of genes from flavonoid biosynthesis pathway during fruit maturation in commercially important cultivars of strawberry. Anti-oxidant, anti-diabetic and anti-glycation activities of mature strawberry fruits have also been analyzed. The effects of strawberry extracts on hyperglycemia, lipid profile, oxidative stress markers and liver function are studied in diabetic animal models at biochemical and molecular level. Modulation in the expression levels of the genes involved in lipid synthesis and transport, transcription factors and inflammatory markers is studied in the diabetic animals.

  • Project 5

    Title: Biochemical and molecular analysis of adipose tissues in type 2 diabetic human subjects

    Central obesity is the principle risk factor for Insulin resistance and Type 2 diabetes in Asian Indian phenotype. The relationship of visceral adipose tissue, which is an active endocrine tissue, with adipocytokines, insulin resistance and lipid profile is not yet clear. The present study aims to study the role of visceral adipose tissues from diabetic and healthy individuals in adiponectin and leptin secretion and their effects on lipid profiles. The animal model mimicking important landmarks of diabetes development is used to study the effects of omega 3 fatty acids on endocrine function of adipose tissues.

  • Project 6

    Title: Effect of pathadi kashay, trimad and omega 3- fatty acids on diabetic dyslipidemic rats

    Type 2 diabetes mellitus is frequently associated with abnormal lipid profiles. Several drugs like statins, niacin and fibrates are available for the treatment of dyslipidemia but they have undesirable side-effects (Krishna, 2011). Herbal medicines are being practiced since thousands of years and they form an important constituent of traditional medicinal systems of India. Herbal medicines involve use of natural elements which helps in eliminating the root cause of the disease (Subramani et al., 2014). These herbal medicines have long recorded history and they were used in ancient Indian, Chinese and Greek, Egyptian medicine for various therapies (Subramani et al., 2014). Polyherbal formulations (PHFs) are known to have high effectiveness and its therapeutic effect is exerted due to the presence of different phytoconstituents (Meena et al., 2009). PHFs result in fewer side effects as compared to allopathic drugs (Krishna, 2011). Although modern allopathic drugs are designed for adequate therapeutic results but administration of most of them comes with unwanted side-effects (Krishna, 2011). Omega 3 fatty acids play an important role in normalizing abnormal lipid profile (Kaithwas and Majumdar, 2012). Pathadi kashay and Trimad are indicated in dyslipidemia in ayurvedic medicine (Ashtang hridaya; Bhavprakash sanvitha) but their therapeutic effects have not been studied against diabetic dyslipidemia.

Publications: 39

Current Team

  • Mr. Abhijit Ghadge (Research Assistant)
  • Ms. Pallavi Mandve (PhD Student)
  • Ms. Tejaswi Chavan (PhD Student)
  • Ms. Shubhangi Harke (PhD Student)
  • Mr. Suresh Khadke (PhD Student)
ICMR Centre for Advanced Research

Recognized “ICMR Centre for Advanced Research - Investigating mechanisms leading to preeclampsia” funded by Indian Council of Medical Research, Government of India. PI: Dr. Sadhana Joshi.

Nomination of Dr. Sadhana Joshi

Dr. Sadhana Joshi nominated to be part of an Expert Group formed to give recommendations to the State Project Directorate, Rashtriya Uchchatar Shiksha Abhiyan RUSA, Department of Higher & Technical Education, Government of Maharashtra on Value Added Courses for emerging & high demand sector of Wellness

Symposium

2nd David Barker Memorial Symposium on Developmental Origins of Health and Disease (DOHaD) on Saturday 18th February 2017

CME by Ministry of AYUSH

CME on Basic Research Techniques for Ayurvedic PG Teachers Contact: Dr. Supriya Bhalerao - 27th February to 4th March 2017

World Obesity Day

On occasion of World Obesity Day, a workshop on Anthropometric assessment was organized by Obesity Research Lab, IRSHA on 13th October 2016. Dr. Sanjay Juvekar and Dr. Hemangi Lubree from Vadu Rural Health Program (VRHP), an initiative of KEM Hospital delivered a lecture on basic techniques of anthropometry followed by demonstration of the anthropometry assessment on volunteers by their team.

National Ayurveda Day

Ministry of AYUSH has declared Dhanateras to be celebrated as National Ayurveda Day. Prof. M S Baghel (Ex- Chairman, Ayurveda Chair University of Debrecan, Hungary) was the special invitee for the auspicious day. He threw light over the Ayurveda concepts of Diabetes, its consequences and its management. A lecture was delivered by Dr. Jyoti Shirodkar (Ayurvedic Diabetologist, Asso. Prof. Dept of Dravyaguna, TAMV) based on the theme Prevention and Control of diabetes using Ayurveda.

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