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Interactive Research School For Health Affairs (IRSHA), Pune

Research Projects


Completed Projects

Completed Projects

Extramural Projects
S.No Title Duration Funding Agency Principle Investigator
1 Disturbed maternal one carbon cycle in preeclampsia increases risk for cardio-metabolic variables in children May 2015- June 2018 Funded by Department of Biotechnology (49.82 lakhs) Dr. Sadhana Joshi
2 Pro-neurotrophins / p75NTR Signalling Contributes to Increased Apoptosis in Preterm Placentae June 2017 – June 2020 Funded by Department of Science and Technology (40.48 lakhs) Dr. Preeti Chavan Gautam
3 Regional brain volumetric and spectroscopic associations with essential fatty acids in outcome of schizophrenia July 2004 - June 2011 University of Georgia, USA (9.12) Dr. Sadhana Joshi
4 Investigations on long term effects of maternal folic acid supplementation for reducing risks associated with non-communicable diseases in adult offspring using rat model January 2006 – December 2008 Department Biotechnology (19.54) Dr. Sadhana Joshi
5 Role of maternal micronutrients on brain neurotrophic factors and cognitive development in Wistar rat offspring March 2010 – February 2013 Department Biotechnology (34.26) Dr. Sadhana Joshi
6 Comparison of plasma & placental proteomic patterns in pregnancy complications May 2010 – April 2013 Department Biotechnology (45.21) Dr. Sadhana Joshi
7 Role of long chain polyunsaturated fatty acids, neurotrophins and vascular endothelial growth factor in mothers with pre-eclampsia and their association with infant growth December 2010 – November 2012 Indian Council of Medical Research, India (19.72) Dr. Sadhana Joshi
8 Fatty Acid Metabolism in non-pregnant women August 2010 – July 2013 Wellcome trust UK (114.37) Dr. Sadhana Joshi
9 Gene Specific Methylation Patterns of Angiogenic Factors in Preeclampsia July 2011 – December 2012 Indian Council of Medical Research, India (23.37) Dr. Sadhana Joshi
10 Multigenerational effects of vitamin B 12 deficiency /supplementation on brain development and metabolic syndrome variables in a rat model. June 2012 – May 2015 Department of Science and Technology (40.05) Dr. Sadhana Joshi
11 Understanding the Risk of Metabolic and Neurodevelopmental Disorders in Infants Born to Mothers with Pregnancy Complications August 2012 – October 2013 Wellcome trust UK (30.55) Dr. Sadhana Joshi
12 Maternal micronutrient status, inflammatory markers and Risk for non- communicable diseases in the offspring in a preeclamptic rat model February 2013 - January 2016 Department Biotechnology (37.62) Dr. Sadhana Joshi
13 Epigenetic regulation of matrix metalloproteinases in preterm placenta February 2012 – January 2015 Department of Science and Technology (52.74) Dr. Preethi Chavan
14 Regulation of fatty acid desaturases and transport protein in pregnancy April 2013 – March 2014 Indian Council of Medical Research (16.90) Dr. Asmita Joshi
15 Regulation of tumor growth through nutritional intervention involving omega-3 fatty acids December 2009 – Jan 2012 Department of Biotechnology (37.24) Dr. Ruchika Kaul - Ghanekar
16 Development of a standardized herbal anti- inflammatory product for management of osteoarthritis June 2010 – May 2012 Department of Biotechnology (43.96) Dr. Ruchika Kaul - Ghanekar
17 A Value Chain on Linseed: Processing and Value Addition for Profitability - Production to Consumption System (PCS) June 2009 – March 2014 ICAR-NAIP II (87.16) Prof. M. V. Hegde
18 Sustainable Rural Livelihood Security in Backward Districts of Maharashtra July 2007 – March 2014 ICAR-NAIP III (235.04) Prof. M. V. Hegde
19 Characterization of bioactive secondary metabolites for anti-inflammatory activity from selected medicinal plants February 2008- January 2009 Department of Biotechnology (0.8) Dr. Suresh Jagtap
20 Medhya activity of Jatamansi, Nardostachys jatamansi (D.Don) DC. with respect to its adultrants and substitutes as evaluated by ADHD (attention deficit hyperactivity disorder) model funded by NMPB January 2010 - December 2013 National Medicinal Plant Board (20.00) Dr. Suresh Jagtap
21 Bioprospecting of Amarkand, traditionally used tubers as a functional food August 2012 – July 2015 Department of Science and Technology (23.27) Dr. Suresh Jagtap
22 Bioresourcing of flax for enhanced omega-3 nutrition April 2004 – March 2008 Department of Biotechnology (39.22) Prof. Abhay Harsulkar
23 Microbial production of omega -3 fatty acids August 2008 – March 2010 Department of Biotechnology (63.00) Prof. Abhay Harsulkar
24 Identification of genes involved during disease development by gall forming rust fungi in Acacia burnean and Jasminum malbaricum April 2009 – March 2012 Department of Biotechnology (46.00) Prof. Abhay Harsulkar
25 Towards improvement of flax for oil and agronomic traits April 2010 – March 2013 Indo-Canada, Department of Biotechnology (59.03) Prof. Abhay Harsulkar
26 Cultivation trials of medicinal plants in agro climatic zones of Maharashtra 2003-2005 Department of Science and Technology (DST) Dr. Suresh Jagtap
27 Sustainable rural livelihoods and conservation of protected Areas 2008-2009 WWF- Delhi Dr. Suresh Jagtap
28 Characterization of bioactive secondary metabolites for anti-inflammatory activity from selected medicinal plants 2008-2009 Department of Biotechnology (DBT) Dr. Suresh Jagtap
29 Bioprospecting of Amarkand, traditionally used tubers as a functional food 2012-2015 Department of Science and Technology (DST) Dr. Suresh Jagtap
30 Regional differences in neurotrophin regulation of vascularization in preeclamptic placentae March 2015 – February 2017 Indian Council of Medical Research (29.94) Dr. Sadhana Joshi
31 Exploring the efficacy of omega 3 fatty acid supplementation to a maternal high fat diet deficient in vitamin B12 in ameliorating the risk for impaired brain development and metabolic syndrome in the offspring. December 2013 – November 2016 Indian Council of Medical Research (20.78) Dr. Anvita Kale
32 Honey as a base for antioxidants in Health foods   Directorate of Science & Technology KVIC, Mumbai (4.95 Lakhs) Dr. M. V. Hegde
33 Egg for health  in collaboration Venkateshwara Hatchery   Department  of Biotechnology (17 Lakhs) Dr. M. V. Hegde
34 New approach to quick biogass production   DST.KVIC (4.9 Lakhs) Dr. M. V. Hegde
35 Direct beta thalassemia carrier detection kit   DBT-BIRAC (44.64 Lakh) Mr. Yogesh Badhe and Dr. M. V. Hegde
Industry Sponsored Projects
1 Effect of Leucronil® tablets in the patients with Leucorrhea: An open clinical trial August 2014 – March 2015 Baidyanath Bhavan Pvt. Ltd. (2.46) Dr. Supriya Bhalerao
2 Pharmacological evaluation of IBIS on streptozotocin induced diabetic complications in laboratory animals January 2012 – December 2013 Indus Biotech Pvt. Ltd. (3.50) Dr. Abhay Harsulkar
3 Nutragenomics study of nutraceutical formulations November 2016 – October 2018 Tata Chemicals Ltd, Pune (10.00) Dr. Abhay Harsulkar
4 Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin in knee osteoarthritis: A randomized double-blind controlled clinical study May 2015 – December 2016 Pharmanza Herbal Pvt. Ltd. (8.97) Dr. Supriya Bhalerao
5 Clinical study to evaluate the safety and efficacy of Herbal Formulation for Obesity (HFO-O2) in overweight individuals February 2016 – December 2016 Baidyanath Bhavan Pvt. Ltd. (2.89) Dr. Supriya Bhalerao
6 Evaluation of cardioprotective activity of an herbal formulation in rat model of isoprenaline induced myocardial infraction 2018 Dabur Research & Development Center, DaburIndia Ltd Dr. Supriya Bhalerao

Ongoing Projects

Ongoing Projects

Extramural Projects
S.No Title Duration Funding Agency Principle Investigator
1 OPTIMISE: Optimal preconception nutrition to offset inflammation and non-communicable disease risk in pregnant women and their children Yet to be initiated Funded by MRC Co-Investigator Dr. Sadhana Joshi
2 Influence of Maternal One-carbon (1C) Metabolism in Placental Function, Fetal Growth and Programming March 2018- Feb 2021 Funded by Department of  Biotechnology.
Total Amount Awarded: 1,61,98,362/-.

IRSHA SHARE: Rs. 6,85,880 /-

Dr. Sadhana Joshi (Co-PI)
3 Early Interventions to Support Trajectories for Healthy Life in India (EINSTEIN). Healthy Life Trajectories Initiative (HeLTI) Dec 2017- Jan 2020 Funded by Department of Biotechnology.
Rs. 7,43,44,024/-
IRSHA SHARE: 1350000
Dr. Sadhana Joshi
4 Epigenetic regulation of angiogenic factors in assisted reproductive technology (ART) and non-ART derived placentae July 2019- July 2022  Funded by Department of Biotechnology.
Amount Awarded: Rs.59,91,300 /-
Dr. Deepali Sunderani
5 Epigenetic regulation of placental peroxisome proliferator activated receptor (PPAR) in women delivering low birth weight babies April 2019- April 2022  Funded by Department of Biotechnology, Government of India.
Amount Awarded: Rs. 35,50,683/-
Dr. Deepali Sunderani
6 Evaluation of Triphala & Trimad for their effects on adipocytes biology and Lipid metabolism 2016 - 2019 Ministry of AYUSH (28.32) Dr. Supriya Bhalerao
7 Evaluating the anti- neoplastic potential of Panchavalkala, an Ayurvedic formulation, in cervical cancer-an in vivo study November 2014 – October 2016 Bharat Seva Sansthan (3.00) Dr. Ruchika Kaul - Ghanekar
8 Developing high oleic safflower genotypes through functional genomics July 2015 – June 2018 ICAR-NASF (46.44) Prof. M. V. Hegde
9 ICAR-AICRP- Linseed Value Addition Centre April 2015 onwards ICAR (15.74 Lakh received as on today). Prof. M. V. Hegde
10 Chemical Diversity and Nutraceutical Potential of Indian Propolis December 2016 – January 2018 Department of Science and Technology (39.12) Dr. Suresh Jagtap
11 Chemical Diversity and Nutraceutical Potential of Indian Propolis 2016-2018 Department of Science and Technology (39.12) Dr. Suresh Jagtap
12 Centre for Advanced Research - Investigating Mechanisms Leading to Preeclampsia March 2017 – February 2022 Indian Council of Medical Research (6.8crores) Dr. Sadhana Joshi
13 Influence of Maternal One-carbon (1C) Metabolism in Placental Function, Fetal Growth and Programming November 2017-November 2020 Funded by Department of  Biotechnology (70 lakhs) Dr. Sadhana Joshi (Co-PI)
14 Evaluation of efficacy of novel stabilized omega-3-fatty acid and antioxidants formulation for the prevention and treatment of metabolic syndrome June 2017 – 2020 DST-SERB (40.36) Dr. Anand A. Zanwar
Synthesis and characterization of cinnamaldehyde-FITC- Folate conjugatedFe3O4 nanoparticles for targeted delivery in breast cancer (12.76 Lakhs; DSTNanomission)
Evaluation of anticancer potential of extracts derived from marine organisms incancerous and non-cancerous cell lines.(10 lakhs, IISER)
Evaluating the anticancer activity of different higher homeopathic potencies (200C, 1M,10M, 50M, CM) of Terminalia chebula (TC) in breast cancer cell lines and analyzing thebest potency for activity against in vivo breast cancer model (42.98 Lakhs; CCRH, AYUSH)
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